Results 61 to 70 of about 396,083 (241)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

City break as a form of urban tourism

open access: yesZeszyty Naukowe Małopolskiej Wyższej Szkoły Ekonomicznej w Tarnowie, 2020
The aim of this paper is to investigate the attractiveness of city break trips as a form of urban (cognitive) tourism. The study focuses on the following research questions: What factors influence the popularity of city break trips? Which cities are most
Agata Balińska
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

The role of perfectionism in enhancing job performance in İzmir destination hotels [PDF]

open access: yes
Perfectionism is the behavior of people who set goals that are difficult to achieve in order to be perfect, to reach perfection and to exhibit high performance.
Çankaya Altuntaş, Cemre   +1 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

City marketing to city branding: A novel practice in Zimbabwe destination branding. [PDF]

open access: yesAfrican Journal of Hospitality, Tourism and Leisure, 2018
This study was based on understanding the concept of city marketing as a driver towards the achievement of effective city brands. The main aim was to develop a new destination branding perspective that originates from city branding. The study employed a
Dr Farai Chigora   +1 more
doaj  

Aspects of the Revelation of the Divine in St. Gregory Palamas’ Treatise De Operationibus Divinis

open access: yesPerichoresis: The Theological Journal of Emanuel University, 2019
In this paper, we examine the concepts ‘destination’, ‘revelation’, ‘foreknowledge’, ‘will’, ‘transmission’, ‘motion’, and ‘grace’, as they appear in Gregory Palamas’ treatise De opera-tionibus divinis.
Terezis Christos, Tempelis Elias
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

An Analysis of the Demand for Tourist Accommodation to Travel with Dogs in Spain

open access: yesSocieties
Pets, generally, and dogs have become an essential part of families. This situation implies that people consider their dogs when planning family holidays, excluding moving to a second home.
José E. Ramos-Ruiz   +3 more
doaj   +1 more source

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