Results 71 to 80 of about 126,448 (268)

An Analysis of the Demand for Tourist Accommodation to Travel with Dogs in Spain

Societies
Pets, generally, and dogs have become an essential part of families. This situation implies that people consider their dogs when planning family holidays, excluding moving to a second home.
José E. Ramos-Ruiz, Minerva Aguilar-Rivero, Jaime Aja-Valle, Lucía Castaño-Prieto   +3 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Tiktok made me book it: The impact of Tiktok on tourism destination selection of generation Z and millennials in Manila

Journal of Hospitality, Tourism & Cultural Research
The advent of social media, with TikTok at the forefront, has transformed the way individuals access information and make decisions, particularly in the context of tourism destination selection.
Sydney Monic U. Alejo, Fernanda Marie M. Cu, Erin Brent D. Reyes, Lorenzo C. Sumang, Marcus Bradley G. Del Poso, Rowena A. Lunar   +5 more
doaj   +1 more source

Destination brand authenticity to destination brand engagement in tourism destination

Technium Social Sciences Journal
This study examines Destination Brand Engagement (DBE) in the context of tourism primarily focusing on its outcomes rather than its antecedents. This study differs from previous studies in examines the impact of destination-centric drivers and tourist-centric perspectives.
Intan Widuri Sakti, null Zakiah Darajat, null Yori Rismayanti   +2 more
openaire   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

The Estimation of Prospects of Development of the Tourist Destination of Saint-Petersburg

Управленческое консультирование, 2018
The paper estimates the prospects of the development of modern tourist destination in St. Petersburg. Methodology assessment served as a well-known tool in strategic management the SWOT-analysis.
Aleksei Igorevich Balashov
doaj  

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source