Results 41 to 50 of about 396,082 (288)

A Conceptual Development of a Business Model Typology in Tourism: the impact of digitalization and location

open access: yesTechnology Innovation Management Review, 2020
This paper aims to conceptually develop a business model typology in tourism. It focuses on digitalization and destination location as important contextual factors when developing the typology.
Gabriel Linton, Christina Öberg
doaj   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Beyond Tourism: The Ways of Salatiga Culinary Business People to Survive Covid-19

open access: yesIndonesian Journal of Tourism and Leisure
During the COVID-19 pandemic, the sustainability of tourism-related livelihoods was significantly impacted. Tourism-related SMEs, including culinary businesses, have strived to find ways to endure the pandemic.
Rio Giovano Setiawan   +1 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Will Generation Z Use ChatGPT for Tourism Recommendations?

open access: yesTourism and Hospitality Management
Purpose – This research note examines Generation Z’s acceptance of ChatGPT as a Tourism Recommender System, to better understand whether they will use it for a tourism recommendation, and the factors influencing their acceptance.
Anom Hery SUASAPHA
doaj   +1 more source

The impact of climate change on visitor destination selection: A case study of the Central Drakensberg Region in KwaZulu-Natal

open access: yesJàmbá, 2021
Many variables influence visitors’ destination choices, for example, affordability, attractions, health and safety, and expectancies. Amongst the indirect influences in destination choice by tourists, climate change is perhaps the greatest factor because
Nduduzo A. Ngxongo
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Destination loyalty explained through place attachment, destination familiarity and destination image

open access: yesInternational Journal of Tourism Research, 2020
AbstractThis study explores how familiarity and attachment, along with cognitive and affective image explain destination loyalty across visitors with divergent degrees of frequency of visitation (low vs. high). Serbians (n= 401) who have previously visited Greece comprised the sample population for this study and were surveyed using a self‐administered
Dimitrios Stylidis   +3 more
openaire   +1 more source

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