Results 31 to 40 of about 396,083 (241)

Turizmde Yeni Ürün Geliştirme ve Pazarlama Stratejileri: Kastamonu Şehir Merkezi Destinasyonu Örneği

open access: yesİşletme Bilimi Dergisi, 2019
Amaç: Turizmden sağlanan gelirlerin kalkınmaya önemli katkılarının olduğu bilinmektedir. Bu katkılarından dolayı turistik destinasyonlar arasındaki rekabet hızla artmaktadır.
Nagehan Büyükmehmetoğlu, Kutay Oktay
doaj   +1 more source

Transverse Strips Instead of Wearable Laser Lights Alleviate the Sequence Effect Toward a Destination in Parkinson's Disease Patients With Freezing of Gait

open access: yesFrontiers in Neurology, 2020
Background: The sequence effect (SE), referring to step-to-step reduction in amplitude, is considered to lead to freezing of gait (FOG) in Parkinson's disease (PD). Visual cues may alleviate SE and help reduce freezing episodes.
Shan-Shan Cao   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Conceptual Development of a Business Model Typology in Tourism: the impact of digitalization and location

open access: yesTechnology Innovation Management Review, 2020
This paper aims to conceptually develop a business model typology in tourism. It focuses on digitalization and destination location as important contextual factors when developing the typology.
Gabriel Linton, Christina Öberg
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Beyond Tourism: The Ways of Salatiga Culinary Business People to Survive Covid-19

open access: yesIndonesian Journal of Tourism and Leisure
During the COVID-19 pandemic, the sustainability of tourism-related livelihoods was significantly impacted. Tourism-related SMEs, including culinary businesses, have strived to find ways to endure the pandemic.
Rio Giovano Setiawan   +1 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Will Generation Z Use ChatGPT for Tourism Recommendations?

open access: yesTourism and Hospitality Management
Purpose – This research note examines Generation Z’s acceptance of ChatGPT as a Tourism Recommender System, to better understand whether they will use it for a tourism recommendation, and the factors influencing their acceptance.
Anom Hery SUASAPHA
doaj   +1 more source

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