Results 91 to 100 of about 109,033 (289)
Analysis of a Modern Voice Morphing Approach using Gaussian Mixture Models for Laryngectomees
, 2012 This paper proposes a voice morphing system for people suffering from Laryngectomy, which is the surgical removal of all or part of the larynx or the voice box, particularly performed in cases of laryngeal cancer.
Chadha, Aman +2 more
core +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Mechanical Circulatory Support and the Role of LVADs in Heart Failure Therapy
Clinical Medicine Insights: Cardiology, 2015 Heart failure is epidemic in the United States with a prevalence of over 5 million. The diagnosis carries a mortality risk of 50% at 5 years rivaling many diagnoses of cancer.
Allison McLarty
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Challenge Patient Dispatching in Mass Casualty Incidents [PDF]
, 2012 Efficient management of mass casualty incidents is complex, since regular emergency medical services struc-tures have to be switched to a temporary “disaster mode” involving additional operational and tactical struc-tures.
Adler, Christine +3 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
FoliumСтаття присвячена дослідженню психотерапевтичного дискурсу сучасного лікаря-психотерапевта і письменника Ірвіна Ялома у фокусі когнітивно-лінгвістичних студій. Метою розвідки є з’ясування діапазону концептуальних метафор з цільовими доменами THERAPEUTIC
Оксана Дойчик +1 more
doaj +1 more source
RoboChain: A Secure Data-Sharing Framework for Human-Robot Interaction
, 2018 Robots have potential to revolutionize the way we interact with the world around us. One of their largest potentials is in the domain of mobile health where they can be used to facilitate clinical interventions.
Ferrer, Eduardo Castelló +3 more
core
Economic evaluation of a nursing-led intermediate care unit [PDF]
, 2001 Objectives: The aim of this paper is to examine the costs of introducing a nursing-led ward program together with examining the impact this may have on patients' outcomes.
Batehup, L +4 more
core +1 more source
IS ILEOANAL POUCH EXCISION A DESTINATION THERAPY FOR INFLAMMATORY BOWEL DISEASE? DATA FROM A QUATERNARY POUCH REFERRAL CENTER [PDF]
, 2021 Sarah Choi +6 more
openalex +1 more source