Results 91 to 100 of about 67,340 (296)
The Role fate and destiny and Personal Agency in the Emergence of Psychological Disorders [PDF]
روانشناسی و روانپزشکی شناختIntroduction: The predestination has always been one of the most important topics in the field of Islamic philosophy, mysticism. This issue not only has a special place in the theoretical and abstract space, but also a profound impact on human ...
Khodadad Asemi +2 more
doaj
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
, 1919 First Line: A rose finds its way to a garden and growsFirst Line of Chorus: Destiny destiny holding each heart in its spellKey: C ...
core
Héroe trágico, nociones de catarsis y de destino en tres textos teóricos de Friedrich Hölderlin
Perífrasis. Revista de Literatura, Teoría y Crítica, 2017 En el siguiente artículo analizaré en primer lugar cómo Friedrich Hölderlin (1770-1843) se distancia de la Poética de Aristóteles al proponer la figura del héroe trágico como fundamento de la tragedia en Grund zum Empedokles [Fundamento para el ...
David Eduardo Alvarado Archila
doaj +1 more source
Advanced Engineering Materials, EarlyView.Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic +2 more
wiley +1 more source
Morphology, Transport, and Dynamics of Protein Adsorption in Open‐Cell Metal Foam
Advanced Engineering Materials, EarlyView.Stainless steel (SS) open‐cell foams are shown to adsorb more protein per unit area than previously reported 316L SS and chromium oxide surfaces under static and flow conditions. An integrated approach combining 3D pore imaging, flow simulation, and protein adsorption experiments characterizes the foam’s performance.
Chinmaya Prerana Inguva +2 more
wiley +1 more source