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TAGing for destruction

Nature Chemical Biology, 2018
Proteins brought to an E3 ubiquitin ligase are polyubiquitylated for rapid degradation via the proteasome. A new study developed a tag-based degradation system using heterobifunctional degradation inducers called dTAGs, which rapidly depleted FKBP12F36V-fused proteins in cultured cells and in mice.
Aisha Yesbolatova, Masato T. Kanemaki
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Data Destruction

The Journal of School Nursing, 2005
School nurses are caretakers of a vast amount of sensitive student and family health information. In schools, older computer hardware that previously stored education records is recycled for less demanding student and employee functions. Sensitive data must be adequately erased before electronic storage devices are reassigned or are discarded.
Martha Dewey Bergren   +2 more
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On destruction in design

ACM SIGCAS Computers and Society, 2021
Sometimes to build something new you have to destroy what exists. We learned what should have been this obvious fact of existence through our collaboration with a group of 7th grade middle school students that we enlisted in a civic design project. The students were nominally tasked with designing new spaces for inter-cultural communication and public ...
Tapan Parikh, Samar Sabie
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Destructive Emotions

Consciousness & Emotion, 2000
This paper discusses the problem of destructive emotions by comparing Eastern and Western assumptions about emotions. In the case of anger, for example, Eastern thinkers straightforwardly posit that it is entirely possible to cultivate attitudes in which anger is naturally absent. In the West, by contrast, it is generally assumed that anger is a “basic”
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Creative Destruction

2013
The creative destruction is used to describe the evolution of a capitalist economy through its endogenous dynamics assumed to be mainly founded on entrepreneurs' decisions and strategies. These strategies aim at strengthening dominant positions on markets in order to give firms more profit and higher control on market evolution.
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