Results 41 to 50 of about 7,047,657 (235)

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An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Construction and Scaling of a Combined Spectral Index-Based Maturity Estimation Model for Cold-Region Japonica Rice

Agronomy
Precise timing of rice harvesting is critical for ensuring grain yield and quality. Traditional manual evaluation methods are highly subjective and time-consuming, highlighting the critical demand for rapid, non-destructive approaches to estimate rice ...
Huiyu Bao, Cong Liu, Junzhe Zhang, Nan Chai, Longfeng Guan, Xiaofeng Wang, Dacheng Wang, Yifan Yan, Shengyu Zhao, Zhichun Han, Xiaofeng Chen, Rongrong Ren, Xuetong Fu, Lin Wang, Haitao Tang, Le Xu, Zhenbang Hu, Qingshan Chen, Zhongchen Zhang   +18 more
doaj   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Leakage Read Fault in Nanoscale SRAM: Analysis, Test and Diagnosis

, 2006
In this paper we study the impact of leakage currents on the operation of SRAM memories fabricated using nanoscale technologies. We show how the leakage currents, flowing through the pass transistors of unselected cells, may affect the read operation ...
Girard, Patrick, Rosinger, Paul, Hashimi, B. M., Dilillo, Luigi, Al-Hashimi, Bashir   +4 more
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March AB, March AB1: new March tests for unlinked dynamic memory faults [PDF]

, 2005
Among the different types of algorithms proposed to test static random access memories (SRAMs), March tests have proven to be faster, simpler and regularly structured. New memory production technologies introduce new classes of faults usually referred to
Di Natale, Giorgio, Bosio, Alberto, A. Benso, P. Prinetto, A. Bosio, G. Di Natale, Benso, Alfredo, Prinetto, Paolo Ernesto, S. Di Carlo, Di Carlo, Stefano   +9 more
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A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Novel Proposal for Strength Prediction of Cement-Stabilized Soils Considering Porosity, Cement Index, and Curing Time

Applied Sciences
Stabilized soils are used as structural components in pavement construction and highway engineering. Due to their broad application, practical methods for predicting their strength are essential.
Maciej Miturski
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

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