Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Measuring the Quality of Species List Contents. [PDF]
BiosciencePape T +25 more
europepmc +1 more source
FORMA: Forest Monitoring for Action— Rapid Identification of Pan-tropical Deforestation Using Moderate-Resolution Remotely Sensed Data [PDF]
Rising concern about carbon emissions from deforestation has led donors to finance UN-REDD (Reducing Emissions from Deforestation and Forest Degradation in Developing Countries), a program that offers direct compensation for forest conservation ...
Dan Hammer, David Wheeler, Robin Kraft
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
A Hierarchical Multi-Resolution Self-Supervised Framework for High-Fidelity 3D Face Reconstruction Using Learnable Gabor-Aware Texture Modeling. [PDF]
J ImagingMareo P, Fooprateepsiri R.
europepmc +1 more source
Will World Bank and IMF Lending Lead to HIPC IV? Debt Déjà-Vu All Over Again [PDF]
Four years ago, the G-7 pushed through an unprecedented initiative forcing the international financial institutions to cancel 100 percent of their outstanding debt claims on the world’s poorest countries.
Benjamin Leo
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Detail is my pencil drawing copied from an image in a 1952 edition of a book on Leonardo da Vinci’s work. At the time of making, I imagined my drawing was an exact reproduction of Leonardo’s Sala Delle Asse. I imagined that, through fidelity to the reproduction, I would come to ‘know’ this work, assimilating it through verisimilitude.
openaire +2 more sources
Transmission line fault detection and classification using bi-orthogonal wavelet transform (5.5) based signal decomposition. [PDF]
Sci RepChothani N +7 more
europepmc +1 more source
Schooling Inequality, Crises, and Financial Liberalization in Latin America [PDF]
Latin America is characterized by high and persistent schooling, land, and income inequalities and extreme income concentration. In a highly unequal setting, powerful interests are more likely to dominate politics, pushing for policies that protect ...
Gunilla Pettersson +2 more
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