Results 111 to 120 of about 1,349,018 (307)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Cassini: Mission to Saturn and Titan [PDF]

The Cassini Mission to Saturn and Titan represents an important step into the exploration of the outerplanets. It will expand on the flyby encounters of Pioneer and Voyager and parallel the detailed exploration of the Jupiter system to be accomplished by
Flury, Walter, Horn, Linda J., Kerridge, Stuart J., Lebreton, Jean-Pierre, Stetson, Douglas S., Stoller, Richard L., Tan, Grace H.   +6 more
core   +1 more source

Hydrodynamical simulations of the decay of high-speed molecular turbulence. I. Dense molecular regions

, 2002
We present the results from three dimensional hydrodynamical simulations of decaying high-speed turbulence in dense molecular clouds. We compare our results, which include a detailed cooling function, molecular hydrogen chemistry and a limited C and O ...
Alexander Rosen, Ballesteros-Paredes, Balsara, Blitz, Burkert, Davis, Georgi Pavlovski, Hartmann, Heitsch, Herbst, Hollenbach, Hollenbach, Katz, Klessen, Langer, Lepp, Lim, Lim, Mac Low, Mac Low, Mac Low, McKee, Michael D. Smith, Mordecai-Mark Mac Low, Neufeld, Padoan, Padoan, Passot, Smith, Smith, Smith, Stone, Stone, Stone, Sutherland, Suttner, Vázquez-Semadeni, Vázquez-Semadeni, Vázquez-Semadeni, Williams   +39 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Detailed open cluster chemistry from ground-based spectroscopy

, 2021
In this talk I speak about how and why we want to understand the chemistry of stellar systems like our galaxy. And then in particular why open clusters are so useful in this context, and which things we have learned from high resolution derived chemistry in the recent years, coupled with the Gaia measurements.
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Microscale Gas Chemistry

Educación Química, 2018
This article starts with a historical overview of the chemistry of gases from the first mention of air by Empedocles down through Lavoisiers Oxygen Theory. Gas generating equipment is reviewed along the way.
Bruce Mattson
doaj   +1 more source

The Physical and Chemical Structure of Hot Molecular Cores

, 2003
We have made self-consistent models of the density and temperature profiles of the gas and dust surrounding embedded luminous objects using a detailed radiative transfer model together with observations of the spectral energy distribution of hot ...
Adams, Adams, Aikawa, Allamandola, Bonnell, Bonner, Brown, Cardelli, Caselli, Caselli, Charnley, Charnley, Chiar, Chini, Churchwell, Collings, Doty, Doty, Draine, Dullemond, Ebert, Ehrenfreund, Falgarone, Fraser, Fuller, Gerakines, H. Nomura, Hasegawa, Hatchell, Hatchell, Hatchell, Heaton, Henning, Ikeda, Kaufman, Keane, Keto, Lahuis, Larson, Larson, Macdonald, Masunaga, McLaughlin, Meyer, Meyer, Millar, Millar, Millar, Millar, Myers, Nakano, Nomura, Palumbo, Rawlings, Rodgers, Schöier, Shu, Shu, T. J. Millar, Thompson, Thompson, van der Tak, van der Tak, Viti, Watt, Willacy, Yorke, Yorke   +67 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Data-Based Hybrid Chemistry Acceleration Framework for the Low-Temperature Oxidation of Complex Fuels

Energies
The oxidation of complex hydrocarbons is a computationally expensive process involving detailed mechanisms with hundreds of chemical species and thousands of reactions.
Sultan Alqahtani, Kevin M. Gitushi, Tarek Echekki   +2 more
doaj   +1 more source