Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Expert system in domain of energy efficiency and failure detection in process industry [PDF]
Expert systems are very suitable for fault detection because they are easy to develop, have capability to reason under uncertainty and the capability to deliver explanations for the solutions provided.
Petković Milena +3 more
doaj
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Optimum response scheme of intrusion detection based on information theory
Intrusion detection system (IDS) often inevitably presents major security risks caused by FPs and FNs.However,at present,an effective solution has not been found.In order to solve this problem,an optimal response model of intrusion detection based on ...
Youliang TIAN, Yulong WU, Qiuxian LI
doaj +2 more sources
Enhancing the detection capability of secondary radar for dense targets
Secondary radar systems primarily detect cooperative targets through an interrogation-response mechanism and are extensively applied in fields such as air traffic control.
Yang Jie, Lai Jiaqing
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Secure routing in the Internet of Things (IoT) with intrusion detection capability based on software-defined networking (SDN) and Machine Learning techniques. [PDF]
Rui K, Pan H, Shu S.
europepmc +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Electronic structures and dielectric function of (5, 5) CNT-C2H4O system: A first-principles study on the detection capability of CNT for gas sensing applications. [PDF]
Pido AAG, Munio AAZ.
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source

