Results 51 to 60 of about 3,842,363 (279)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Research on detection of transmission line corridor external force object containing random feature targets

Frontiers in Energy Research
With the objective of achieving “double carbon,” the power grid is placing greater importance on the security of transmission lines. The transmission line corridor has complex situations with external force targets and irregularly featured objects ...
Hongbo Zou, Hongbo Zou, Ziyong Ye, Jialun Sun, Junting Chen, Qinhe Yang, Yanhui Chai   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Higher capability maturity dynamics of UK construction organisations [PDF]

This paper attempts to identify the dynamics of the CMM (Capability Maturity Model) higher capability maturity level characteristics within the UK construction context from a theoretical perspective.
Amaratunga, Dilanthi, Haigh, Richard, Keraminiyage, Kaushal   +2 more
core   +3 more sources

The impact of artificial intelligence integration on production quality assurance: The role of fault detection capability [PDF]

International Journal of Data and Network Science
The growing adoption of artificial intelligence (AI) in production systems has revolutionized quality assurance processes. Fault detection capability is a critical enabler of production performance and process variability reduction. This study
Qasem Nijem, Mahmoud Allahham, Zain Bashtawi, Nawwaf Hamid Salman Alfawaerh   +3 more
doaj   +1 more source

Enhancing the accuracy of automatic eddy detection and the capability of recognizing the multi-core structures from maps of sea level anomaly [PDF]

Ocean Science, 2014
Automated methods are important for automatically detecting mesoscale eddies in large volumes of altimeter data. While many algorithms have been proposed in the past, this paper presents a new method, called hybrid detection (HD), to enhance the eddy ...
J. Yi, Y. Du, Z. He, C. Zhou
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Context modelling in capability management

, 2018
In the capability-driven development (CDD) approach, a capability is defined by specific business services, a defined application context for these business services, and goals of the enterprise to be reached.
Koç, Hasan,, Sandkuhl, Kurt,
core   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source