Results 91 to 100 of about 4,678,990 (294)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Ag@WO3 core–shell nanocomposite for wide range photo detection

open access: yesScientific Reports
This study successfully synthesized high-performance photodetectors based on Ag-WO3 core–shell heterostructures using a simple and economical two-step pulsed laser ablation in water method and has investigated the electrical characteristics of the Ag@WO3
Jehan A. Saimon   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Optical System and Detection Range Analysis of Synthetic Aperture Ladar

open access: yesLeida xuebao, 2018
Optical system and detection range of Synthetic Aperture Ladar (SAL) are analyzed. According to the imaging characteristics of SAL, the concept that SAL uses non-imaging diffractive optical system are proposed, meanwhile, the phased array model is ...
Li Daojing, Hu Xuan
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Lightweight Ship Detection Network for SAR Range-Compressed Domain

open access: yesRemote Sensing
The utilization of Synthetic Aperture Radar (SAR) for real-time ship detection proves highly advantageous in the supervision and monitoring of maritime activities.
Xiangdong Tan   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Face Inversion Disproportionately Disrupts Detection of Vertical versus Horizontal, Not Long-Range versus Short-Range, Spatial Relations

open access: yesi-Perception, 2011
Presenting a face inverted disrupts sensitivity to the spacing between the features. Recent evidence suggests that inversion disproportionately affects sensitivity to vertical over horizontal changes in eye position.
Kate Crookes, William G. Hayward
doaj   +1 more source

A Study of Ineffective Investment Trust and Precious Metal Mining Issues [PDF]

open access: yes, 1937
Inobject/target reconstruction and recognition based on laser radar data, the range value's accuracy is important. The range data accuracy depends on the accuracy in the laser radar's detector, especially the algorithm used for time-of-flight estimation.
Chevalier, Tomas   +3 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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