Results 131 to 140 of about 1,035,998 (303)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

MSE lower bounds conditioned by the energy detector [PDF]

, 2007
A wide variety of processing incorporates a binary detection test that restricts the set of observations for parameter estimation. This statistical conditioning must be taken into account to compute the Cramer-Rao bound (CRB) and more generally, lower ...
Chaumette, Eric, Renaux, Alexandre, Larzabal, Pascal, Galy, Jerome, Vincent, François   +4 more
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

An interband cascade laser based heterodyne detector with integrated optical amplifier and local oscillator

Nanophotonics
Heterodyne detection based on interband cascade lasers (ICL) has been demonstrated in a wide range of different applications. However, it is still often limited to bulky tabletop systems using individual components such as dual laser setups, beam shaping
Dal Cin Sandro, Windischhofer Andreas, Pilat Florian, Leskowschek Michael, Pecile Vito F., David Mauro, Beiser Maximilian, Weih Robert, Koeth Johannes, Marschick Georg, Hinkov Borislav, Strasser Gottfried, Heckl Oliver H., Schwarz Benedikt   +13 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Data Quality Monitoring and Performance Studies of the Resistive Plate Chamber Detector at the CMS Experiment at LHC. [PDF]

, 2010
The CMS detector is a sophisticated and massive system: 7 different detector technologies, a high number of front-end electronic channels (10^7) , an input rate of 10^9 interactions per second, a trigger able to reduce the frequency by a factor 10^5, and
Cimmino, Anna
core  

Selective Detection of Mercury Ion Using a Carboxamide Based Probe: Synthesis, Spectroscopic and Theoretical Investigation

ECS Sensors Plus
A carboxamide based fluorescent probe N ^2 , N ^6 -bis(5-(4-chlorophenyl)thiazol-2-yl)pyridine-2,6-dicarboxamide (L) was synthesized by the condensation reaction between pyridine-2,6-dicarboxylic and amino derivative of thiazole.
Sanket Kumar Chakravarti, Abhay Nanda Srivastva, Som Shankar Dubey, Anand Kumar Anand, Manish Kumar, Netra Pal Singh   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source