Results 191 to 200 of about 2,140,853 (301)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Advances in High-Temperature Irradiation-Resistant Neutron Detectors. [PDF]

Sensors (Basel)
Wang C, Yu R, Xia W, Gong J.
europepmc   +1 more source

MalGen: Malware Generation with Specific Behaviors to Improve Machine Learning-based Detectors

, 2022
Michael Smith, Armida Carbajal, Eva Domschot, Nicholas Johnson, Akul Goyal, Christopher R. Lamb, Joseph Lubars, William Kegelmeyer, Raga Krishnakumar, Sophie Quynn, Ramyaa Ramyaa, Stephen Verzi, Xin Zhou   +12 more
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Evaluation of an event-driven 3FI ASIC for spectroscopic X-ray detection with synchrotron radiation. [PDF]

J Synchrotron Radiat
Maj P, Deptuch GW, Gorni DS, Pinaroli G, Carini GA, Siddons DP, Tappero R, Mandal S, Pinelli D, Kersten T, St John N, Rumaiz AK, Kuczewski A.   +12 more
europepmc   +1 more source

A Solar Power Regulation System Equipped with Intelligent Solar Power Detector [PDF]

, 2017
Shun‐Yu Chan, Yong‐Nong Chang, Hung‐Liang Cheng, Yih‐Her Yan, H Patel, V Agarwal, A Abdelsalam, A Massoud, S Ahmed, P Enjeti, G Carannante, C Fraddanno, M Pagano, L Piegari, D Sera, L Mathe, T Kerekes, S Spataru, R Teodorescu, C Murdoch, S Reynoso, A Nabulsi, R Dhaouadi, Y Chang, H Cheng   +24 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Upgrade of the Coherent X-ray Scattering beamline at Pohang Light Source II. [PDF]

J Synchrotron Radiat
Ham D, Nam D, Song C, Lee SY.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Auto-thresholding for unbiased electron counting. [PDF]

Microscopy (Oxf)
Bekkevold JM, Peters JJP, Ishikawa R, Shibata N, Jones L.   +4 more
europepmc   +1 more source