Results 201 to 210 of about 2,823,042 (391)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal +8 morewiley +1 more sourceProbing lepton flavour violation via neutrinoless $$\varvec{\tau \longrightarrow 3\mu }$$ τ ⟶ 3 μ decays with the ATLAS detector [PDF]
, 2016 G. Aad, B. Abbott, J. Abdallah, O. Abdinov, R. Aben, M. Abolins, O. S. AbouZeid, H. Abramowicz, H. Abreu, R. Abreu, Y. Abulaiti, B. S. Acharya, L. Adamczyk, D. L. Adams, J. Adelman, S. Xella, T. Adye, A. A. Affolder, T. Agatonović-Jovin, J. Agricola, J. A. Aguilar–Saavedra, S. P. Ahlen, F. Ahmadov, G. Aielli, H. Åkerstedt, T. P. A. Åkesson, A. V. Akimov, G. L. Alberghi, J. Albert, S. Albrand, M. J. Alconada Verzini, M. Aleksa, I. N. Aleksandrov, C. Alexa, G. Alexander, T. Alexopoulos, M. Alhroob, G. Alimonti, L. Alio, J. Alison, S. P. Alkire, B. M. M. Allbrooke, P. P. Allport, A. Aloisio, A. Alonso, F. Alonso, C. Alpigiani, A. Altheimer, B. Álvarez González, D. Álvarez Piqueras, M. G. Alviggi, B. T. Amadio, K. Amako, Y. Amaral Coutinho, C. Amelung, D. Amidei, S. P. Amor Dos Santos, A. Amorim, S. Amoroso, N. Amram, G. Amundsen, C. Anastopoulos, L. S. Ancu, N. Andari, T. Andeen, C. F. Anders, C. F. Anders, J. K. Anders, K. J. Anderson, A. Andreazza, V. Andrei, S. Angelidakis, I. Angelozzi, P. Anger, A. Angerami, F. Anghinolfi, A. V. Anisenkov, N. Anjos, A. Annovi, M. Antonelli, А. Антонов, J. Antos̆, F. Anulli, M. Aoki, L. Aperio Bella, G. Arabidze, Y. Arai, J. P. Araque, A. T. H. Arce, F. A. Arduh, J-F. Arguin, S. Argyropoulos, M. Arik, A. J. Armbruster, O. Arnaez, H. Arnold, M. Arratia, O. Arslan, A. Artamonov, G. Artoni +99 moreopenalex +1 more sourcePYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu +13 morewiley +1 more sourceIn vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni +14 morewiley +1 more sourceInhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge +18 morewiley +1 more sourceCommercially Fabricated Antenna-Coupled Transition Edge Sensor Bolometer Detectors for Next-Generation Cosmic Microwave Background Polarimetry Experiment [PDF]
, 2020 Aritoki Suzuki, Nicholas Cothard, Adrian T. Lee, Michael D. Niemack, Christopher Raum, Mario Renzullo, Trevor Sasse, Jason Stevens, Patrick Truitt, Eve Vavagiakis, John Vivalda, Benjamin Westrook, Daniel Yohannes, Aritoki Suzuki, Nicholas Cothard, Adrian T. Lee, Michael D. Niemack, Christopher Raum, Mario Renzullo, Trevor Sasse, Jason Stevens, Patrick Truitt, Eve Vavagiakis, John Vivalda, Benjamin Westrook, Daniel Yohannes +25 moreopenalex +1 more source
