Results 121 to 130 of about 93,770 (286)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Learnable edge detectors can make deep convolutional neural networks more robust.
PLoS ONEDeep convolutional neural networks (DCNNs) are vulnerable to examples with small perturbations. Improving DCNNs' robustness is of great significance to the safety-critical applications, such as autonomous driving and industry automation.
Jin Ding +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2017 In the WADAPT project described in this Letter of Intent, we propose to develop wireless techniques for data and power transmission in particle-physics detectors.
Djurcic, Z +20 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Image Retrieval Using Dynamic Weighting of Compressed High Level Features Framework with LER Matrix
Iranian Journal of Electrical and Electronic Engineering, 2018 In this article, a fabulous method for database retrieval is proposed. The multi-resolution modified wavelet transform for each of image is computed and the standard deviation and average are utilized as the textural features.
S. Tannaz, T. Sedghi
doaj
Evaluation and synthesis of perovskite crystals as high-Z sensors for hybrid pixel detectors
Scientific ReportsHigh-energy photon imaging experiments are crucial techniques in synchrotron facilities, often employing hybrid pixel detectors for these operations.
R. B. Campanelli +10 more
doaj +1 more source
Advanced Detectors for Nuclear, High Energy and Astroparticle Physics
, 2018 The book presents high-quality papers presented at a national conference on ‘Advanced Detectors for Nuclear, High Energy and Astroparticle Physics’. The conference was organized to commemorate 100 years of Bose Institute.
Ghosh, Sanjay +2 more
core +1 more source