Results 211 to 220 of about 256,768 (386)

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

open access: yesChemMedChem, EarlyView.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska   +5 more
wiley   +1 more source

Mass spectrometry in ocular drug research

open access: yesMass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo   +6 more
wiley   +1 more source

Expression, purification and preliminary pharmacological characterization of the Plasmodium falciparum membrane-bound pyrophosphatase type 1. [PDF]

open access: yesPLoS One
Liu J   +7 more
europepmc   +1 more source

On the institutional innovation process : EU regulation through an evolutionary lens [PDF]

open access: yes
The focal point of this paper is the study of the process of emergence of novel institutions and the identification of factors that may influence the outcome of this process.
Evita Paraskevopoulou
core  

High‐Throughput and Automated Anion Transport Assays

open access: yesChemistry–Methods, EarlyView.
Synthetic ion transporters show promise as therapeutics, but assessing their activity can be time‐consuming, limiting the screening of large compound libraries. We developed an automated high‐throughput assay that determines 24 EC50 values in one day.
Kylie Yang   +7 more
wiley   +1 more source

Unsymmetric Triazine-Based Triglucoside Detergents for Membrane Protein Stability. [PDF]

open access: yesChembiochem
Ehsan M   +11 more
europepmc   +1 more source

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