Results 231 to 240 of about 763,759 (269)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Validation and Psychometric Evaluation of the Persian Version of the Nurse Intuition Patient Deterioration Scale: A Methodological Study. [PDF]

Nurs Open
Nemati-Vakilabad R, Jafari MJ, Mirzaei A, Haegdorens F, Ramazanzadeh N, Gardashkhani S, Shahmari M.   +6 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Optimizing Traumatic Brain Injury Care Without Neurosurgeons: External Validation of the Brain Injury Guidelines in a Resource-Limited Trauma System. [PDF]

J Clin Med
Santin S, Joseph B, Possiedi RD, Pacheco LS, De Santana LP, Wade CMR, Fontenelle Ribeiro MA.   +6 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Availability and restrictiveness of community treatment orders across 33 European countries. [PDF]

BJPsych Open
Rugkåsa J, Aluh DO, Chihai J, Birkeland SF, Chatzittofis A.   +4 more
europepmc   +1 more source

Prognostic associations between patient-reported outcomes and overall survival among patients with advanced squamous non-small cell lung cancer: results from the RATIONALE-307 trial. [PDF]

Qual Life Res
Wang J, Yu X, Leaw S, Barnes FB, Victor T, Barnes G.   +5 more
europepmc   +1 more source

Heterogeneous frailty trajectories and their differential impact on social integration in older adults with COPD: a prospective longitudinal study. [PDF]

Front Public Health
Feng L, Ji H, Jiang Z, Liang M.
europepmc   +1 more source

Effects of Deheading and Intestinal Removal on Protein Degradation and Quality Changes in Chilled <i>Litopenaeus vannamei</i>. [PDF]

Foods
Jia S, Zhao Y, Zhuang S, Zeng H, Chang J, Liu S, Ding Y, Zhou X, Wang Y.   +8 more
europepmc   +1 more source