Results 41 to 50 of about 508,275 (247)
Determining Environmental Determinism
Progress in Human Geography, 2012 This commentary is a direct response to the Forum article ‘Environmentalist thinking and/in geography’ by Radcliffe et al. (2010) . Two main problems are addressed: the perpetuation of a false analogy between cultural and biological evolution, and a misunderstanding of memes.
openaire +5 more sources
رابطهی بین سرمایهی اجتماعی با سطح بهداشت روانی
مدیریت اطلاعات سلامت, 2013 مقدمه: تمرکز بر مقولهی سرمایهی اجتماعی در سالهای اخیر مبتنی بر تأثیر آن در افزایش و تولید سرمایههای انسانی و همچنین بالا بردن سطح سلامت عمومی جامعه بوده است.
Mahmoud Keyvanara +3 more
doaj
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Understanding mechanisms: opening the “black box” in observational studies
Scandinavian Journal of Work, Environment & Health, 2013 New statistical methods are increasingly being used in epidemiology. One of the most interesting developments is the new field of causal inference.
Petter Kristensen, Odd O Aalen
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Indian Journal of Dental Research, 2013 Background: Dental caries is one of the most common chronic diseases of early childhood. Dental problems in early childhood have been shown to be predictive of future dental problems, growth and development by interfering with comfort, nutrition ...
Abhay M Gaidhane +4 more
doaj +1 more source
Nuclear Physics B, 1993 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fuchs, Jürgen, Ringwald, Andreas
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source