Results 171 to 180 of about 4,459 (203)

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

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Decompositions of determinantal varieties

Frontiers of Mathematics in China, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Zhao, Xu'an, Gao, Hongzhu, Su, Xiaole
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Linear Sections of Determinantal Varieties

American Journal of Mathematics, 1988
The author develops an elegant general approach in order to study a genericity property of determinantal varieties, which has several applications. Regarding a surjective pairing \(\mu:\quad A\otimes B\to C\) of finite dimensional vector spaces over an algebraically closed field as a subspace M of \(Hom(A^*,B)\), the author says that M is k-generic if ...
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Determinantal varieties and symmetric polynomials

Functional Analysis and Its Applications, 1987
The paper is a research announcement of some of the author's recent results concerning degeneracy loci. Let X be a scheme over a field and \(\phi: F\to E\) a morphism of vector bundles over X. For every \(r\geq 0\) the degeneracy locus of rank r associated with \(\phi\) is defined as \(D_ r(\phi)=\{x\in X,\quad rk(\phi (x))\leq r\}.\) In analogy with ...
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Linear sections of determinantal varieties

Theoretical and Natural Science
Denote Mmn(k) to be the set of all m n matrices over k, and PMmn(k) to be its affine space. Let Dm,n,r PMmn(k) be the subvariety consisting of the projective classes of all m n matrices with rank less than or equal to r. We study the minimal integer k > 0 such that for any linear subspace L of dimension k in PMmn(k), Dm,n,r L = .
openaire   +1 more source

Determinantal Varieties

2015
V. Lakshmibai, Justin Brown
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Topological Invariants from Determinantal Varieties

This paper investigates the derivation and computation of topological invariants for determinantal varieties, which are fundamental objects in algebraic geometry arising as loci where the rank of a matrix drops below a certain value. Determinantal varieties exhibit rich singular structures, making the computation of their topological invariants ...
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