Results 171 to 180 of about 4,433 (184)

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Decompositions of determinantal varieties

Frontiers of Mathematics in China, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Zhao, Xu'an, Gao, Hongzhu, Su, Xiaole
openaire   +2 more sources

Linear Sections of Determinantal Varieties

American Journal of Mathematics, 1988
The author develops an elegant general approach in order to study a genericity property of determinantal varieties, which has several applications. Regarding a surjective pairing \(\mu:\quad A\otimes B\to C\) of finite dimensional vector spaces over an algebraically closed field as a subspace M of \(Hom(A^*,B)\), the author says that M is k-generic if ...
openaire   +2 more sources

Determinantal varieties and symmetric polynomials

Functional Analysis and Its Applications, 1987
The paper is a research announcement of some of the author's recent results concerning degeneracy loci. Let X be a scheme over a field and \(\phi: F\to E\) a morphism of vector bundles over X. For every \(r\geq 0\) the degeneracy locus of rank r associated with \(\phi\) is defined as \(D_ r(\phi)=\{x\in X,\quad rk(\phi (x))\leq r\}.\) In analogy with ...
openaire   +2 more sources

Linear sections of determinantal varieties

Theoretical and Natural Science
Denote Mmn(k) to be the set of all m n matrices over k, and PMmn(k) to be its affine space. Let Dm,n,r PMmn(k) be the subvariety consisting of the projective classes of all m n matrices with rank less than or equal to r. We study the minimal integer k > 0 such that for any linear subspace L of dimension k in PMmn(k), Dm,n,r L = .
openaire   +1 more source

Determinantal Varieties

2015
V. Lakshmibai, Justin Brown
openaire   +1 more source

Topological Invariants from Determinantal Varieties

This paper investigates the derivation and computation of topological invariants for determinantal varieties, which are fundamental objects in algebraic geometry arising as loci where the rank of a matrix drops below a certain value. Determinantal varieties exhibit rich singular structures, making the computation of their topological invariants ...
openaire   +1 more source