Results 141 to 150 of about 1,835,027 (350)

Inmigración ilegal, aplicación de la ley en la frontera y salarios relativos: elementos de juicio sobre las detenciones en la frontera entre EE.UU. y México [PDF]

(Disponible en idioma inglés únicamente) En este trabajo se analizan los factores determinantes de la inmigración ilegal hacia EE. UU. desde México desde 1976 hasta 1995.
Antonio Spilimbergo, Gordon H. Hanson
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Tough Policies, Incredible Policies? [PDF]

We revisit the question of what determines the credibility of macroeconomic policies here, of promises to repay public debt. Almost all thinking on the issue has focused on governments' strategic decision to default (or erode the value of outstanding ...
Alejandro Neut, Andres Velasco
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The Rise and Fall of Income Inequality in Latin America [PDF]

Este artículo documenta el patrón de auge y caída de la desigualdad del ingreso en América Latina en el período 1980-2008 y presenta posibles determinantes de estas tendencias.
Leonardo Gasparini, Nora Lustig
core  

Emprendimiento senior: determinantes e importancia económica [PDF]

, 2018
Ante un mundo en el que la población envejece a un ritmo muy acelerado, las economías de los países se ven afectadas, por lo que tienen que buscar alternativas para cubrir todos los gastos que conlleva mantener a una población tan longeva.
Navarro León, María Azahara
core  

Determinantal Sieving

TheoretiCS
We introduce determinantal sieving, a new, remarkably powerful tool in the toolbox of algebraic FPT algorithms. Given a polynomial $P(X)$ on a set of variables $X=\{x_1,\ldots,x_n\}$ and a linear matroid $M=(X,\mathcal{I})$ of rank $k$, both over a field $\mathbb{F}$ of characteristic 2, in $2^k$ evaluations we can sieve for those terms in the monomial
Eduard Eiben, Tomohiro Koana, Magnus Wahlström   +2 more
openaire   +2 more sources

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source