Results 241 to 250 of about 61,854,756 (298)
Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel +15 more
wiley +1 more source
Programming of Complex Magnetic Profiles Enforced by 4D Printed Magnetic LCE Actuators
A 4D printing‐enabled magnetic programming strategy is introduced in which thermally actuated liquid crystal elastomers are magnetized in their target shape to encode complex three‐dimensional magnetic profiles. The resulting actuators achieve multistate shape morphing and programmable locomotion under low magnetic fields, without requiring specialized
Erick R. Espíndola‐Pérez +5 more
wiley +1 more source
ABSTRACT Climate change is having significant demographic and health impacts on human populations around the world. There is growing empirical evidence about the impacts of climate variability and change on population health, but this work has focused disproportionately on children and aggregate indicators of weight and (or) height.
Alfredo J. Rojas Jr +3 more
wiley +1 more source
Secular Trend in Age at Menarche and Associated Determinants in the Valencian Population (Spain)
The graphical abstract illustrates changes in age at menarche in the Valencian population (Spain) over nearly eight decades and its association with anthropometric and sociodemographic factors. ABSTRACT Objective To assess secular trend in age at menarche spanning nearly eight decades and to explore variations in these patterns according to selected ...
Andrea Beneito +11 more
wiley +1 more source
ABSTRACT Cognitive behavioral therapy (CBT) is a well‐established, evidence‐based treatment for common mental disorders such as depression, anxiety disorders, and obsessive‐compulsive disorder (OCD). However, treatment outcomes vary widely, and a substantial proportion of patients do not achieve sufficient improvement.
Julia Bäckman +41 more
wiley +1 more source
ABSTRACT This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive‐compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 27,500 individuals across diverse ancestries and clinical populations for genetic analysis within the NIMH
Ana M. Diaz‐Zuluaga +36 more
wiley +1 more source
The Baboon as a Model to Study Human Health and Complex Disease
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley +1 more source
Abstract INTRODUCTION The social exposome is increasingly recognized as a key determinant for cognitive health. Adverse policing represents an understudied aspect of the social exposome, reflecting persistent encounters with punitive surveillance and law enforcement that accumulate as chronic structural stressors across the life span.
Erika Pugh +3 more
wiley +1 more source
Operationalizing Alzheimer's disease trials in the era of targeted therapies
Abstract The therapeutic landscape of Alzheimer's disease (AD) is rapidly evolving with the clinical adoption of anti‐amyloid monoclonal antibodies (mAbs) despite an incomplete understanding of disease mechanisms, progression, and heterogeneity. Designing both observational longitudinal cohorts and clinical trials with novel mAbs in mind is imperative.
Jagan A. Pillai +12 more
wiley +1 more source
Post mortem MRI of cholinergic white matter pathways across neurodegenerative diseases
Abstract INTRODUCTION Cholinergic white matter pathway (CWMP) degeneration is central in Alzheimer's disease (AD) and Lewy body disease (LBD). CWMP degeneration can be assessed in vivo using magnetic resonance imaging (MRI) proxies, but neuropathological validation is limited.
Francisco J. López‐González +9 more
wiley +1 more source

