Results 141 to 150 of about 1,261,490 (308)
External Determinants of Growth and Growth Projections: SAARC and Pakistan [PDF]
In the global trading arena, the regional integration perhaps represents the most important legacy of the 20th century. This paper focuses on the scope and promise of economic cooperation between the SAARC region countries. Descriptive statistics is used
Faiza Amjad, Naheed Zia Khan
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Growth determinants of start-ups in Eastern Germany: a comparison between innovative and non-innovative firms [PDF]
This empirical analysis deals with the determinants of growth and the explanation of variations in the growth between innovative and non-innovative start-ups.
Almus, Matthias +2 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Health Science ReportsBackground and Aims Domestic violence during pregnancy harms the mother‐child bond and can affect fertility decisions. The study aims to Comparison of Maternal‐Fetal Attachment and Fertility Motivation in Pregnant Women with and without Experience of ...
Mina Abbasi +4 more
doaj +1 more source
Determinants of Growth in Indonesia
KEMUDI : Jurnal Ilmu Pemerintahan, 2019 Paper ini bertujuan untuk mengidentifikasi faktor-faktor penentu pertumbuhan ekonomi di Indonesia. Untuk itu, dilakukan analisis terhadap data panel dari 33 provinsi di Indonesia mulai tahun 2006 sampai 2015. Analisis empiris pada paper ini melibatkan dua metode estimasi: 1) Ordinary Least Squares (OLS) dengan Fixed Effects Model, dan 2) Generalized ...
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Macroeconomic Determinants of Economic Growth in Pakistan [PDF]
The main purpose of this paper has been to examine the effects of some of the key macroeconomic variables on Pakistan’s economic growth. Multiple regression framework is used to separate out the effects of key macroeconomic factors on growth over the ...
Ghulam Mustafa Zahid, Zafar Iqbal
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source