Results 161 to 170 of about 1,853,500 (222)

Carbon Materials in Voltammetry: An Overview of Versatile Platforms for Antidepressant Drug Detection. [PDF]

Micromachines (Basel)
Smajdor J, Fendrych K, Górska-Ratusznik A.   +2 more
europepmc   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, Volume 19, Issue 5, Page 1386-1403, May 2025.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Robust sex determination in the Caenorhabditis nigoni germ line. [PDF]

Genetics
Harbin JP, Shen Y, Lin SY, Kemper K, Haag ES, Schwarz EM, Ellis RE.   +6 more
europepmc   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Heat inducible nuclear translocation of Kdm6bb drives temperature dependent sex reversal in Nile tilapia. [PDF]

PLoS Genet
Lu J, Huang S, Wei S, Cheng J, Li W, Fei Y, Yang J, Hu R, Huang S, Zhai W, Wu Z, Liu M, Xu Q, Hu P, Chen L.   +14 more
europepmc   +1 more source

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

Molecular Oncology, Volume 19, Issue 4, Page 1203-1228, April 2025.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso, Shivani Bailey, Luz Alonso‐Crisostomo, Dawn Ward, Christos Panayi, Zachary G. L. Scurlock, Harpreet K. Saini, Stephen P. Smith, James C. Nicholson, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray   +12 more
wiley   +1 more source

Gut microbiota diversity is prognostic and associated with benefit from chemo‐immunotherapy in metastatic triple‐negative breast cancer

Molecular Oncology, Volume 19, Issue 4, Page 1229-1243, April 2025.
We assessed the associations between the gut microbiota and outcome in metastatic triple‐negative breast cancer patients treated with chemotherapy alone or chemotherapy in combination with immunotherapy. Our data indicate that high gut microbiota alpha diversity was associated with improved clinical outcome and with benefit from immunotherapy.
Andreas Ullern, Kristian Holm, Andreas Hagen Røssevold, Nikolai Kragøe Andresen, Corinna Bang, Ole Christian Lingjærde, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +8 more
wiley   +1 more source

Economic Impacts of Ultrasonographic Fetal Sex Determination on Hanwoo Cattle Profitability and Market Dynamics. [PDF]

Vet Sci
Kim D, Son M, Jung D, Heo S, Kim M, Yi J.   +5 more
europepmc   +1 more source

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang, Hei Ip Hong, Victor C. Y. Mak, Yuan Zhou, Yiling Lu, Guanglei Zhuang, Lydia W. T. Cheung   +6 more
wiley   +1 more source

Organ donation under V-A ECMO support: insights and recommendations from Japan's first two cases. [PDF]

Resusc Plus
Nagashima F, Matsui D, Hazama T, Takasu K, Matsuda T, Nakai T, Kageyama N, Oda T, Nagata J, Sugie E, Yamaoka Y.   +10 more
europepmc   +1 more source