Analysis of definition «social responsibility» and its intergrated interpretation in pharmacy
It is not possible to introduce the basic principles of social responsibility (SR) by domestic pharmaceutical enterprises without analysis of international experience.
N. О. Tkachenko
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
On some morphological properties of the adjective in Gothic
The morphology of Gothic, as well as that of other older Germanic languages, has traditionally been analysed in phonological terms, with classifications that reflect earlier stages in the development of Germanic.
Artūras Ratkus
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Atomic absorption spectrometry in wine analysis
This article reviews methods for the determination and identification of trace elements in wine by using atomic absorption spectrometry (AAS). Wine is one of the most widely consumed beverages and strict analytical control of trace elements content is ...
Trajče Stafilov, Irina Karadjova
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Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
ABOUT THE LOAD FACTOR OF POWER TRANSFORMERS OF THE RAILWAY TRACTION SUBSTATIONS
The author has proposed the criterion and method of determination of optimum load factors of power transformers of railway traction substations.
V. H. Kuznetsov
doaj
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Organogenesis during plant regeneration in cotyledon culture of Trifolium michelianum Savi
Shoots of Trifolium michelianum Savi. could be induced directly from the cotyledonary petiole or through petiole-derived callus on EC6 medium (Mahewswaran and Williams 1984) supplemented with BAP at 4.4, 8.8 and 22.2 µM.
Robert Konieczny
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