Results 51 to 60 of about 318,468 (322)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Referentiality and the Noun

open access: yesHermes, 2011
This paper argues that nouns and names, as such, do not refer. Apparently-referring nouns and names have been converted lexically to determiners. Thus nouns and names participate in reference by virtue of dependency on a determiner, either in the syntax,
John Anderson
doaj   +1 more source

Les constructions de type Nc-Npr avec et sans déterminant :comparaison français-allemand

open access: yesCorela, 2023
This French and German contrastive study is about constructions made of a noun phrase (sometimes limited to a single noun) and a name, such as Le capitaine Haddock / Kapitän Haddock ; l’oncle Charles /Onkel Karl ; Le poète Gottfried Benn /der Dichter ...
Stéphanie Benoist
doaj   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

open access: yesMolecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova   +26 more
wiley   +1 more source

Perceptual determinants of phrase boundary placement [PDF]

open access: yesThe Journal of the Acoustical Society of America, 1976
In speech production many acoustic cues are correlated with the presence of a major syntactic boundary. Here the relative contribution of three acoustic cues, fundamental frequency contour, duration, and amplitude to perceptual segmentation process was evaluated. The stimuli were ambiguous algebraic expressions, such as “A times E plus 0,” in which the
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Syntactic Features of Proper Names: The Generativist Approach(es) to Properhood [PDF]

open access: yesВопросы ономастики, 2018
The paper presents an overview of the generativist approaches to the syntactic analysis of proper names which are only very little known in the field of onomastics.
Eugenia E. Romanova   +1 more
doaj   +1 more source

Gender assignment and gender agreement in advanced French interlanguage: a cross-sectional study [PDF]

open access: yes, 2001
An analysis of 519 gender errors (out of 9,378 modifiers) in the advanced French interlanguage of 27 Dutch L1 speakers confirms earlier findings that gender assignment and/or agreement remain problematic for learners at all levels.
Dewaele, Jean-Marc, Véronique, D.
core   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

open access: yesFEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki   +3 more
wiley   +1 more source

Adjective Syntax and (the absence of) noun raising in the DP [PDF]

open access: yes, 2008
The paper is structured as follows. Section 2.1 introduces the basic classes of adjectives that constitute the factual core of the paper. Section 2.2 summarizes in greater detail the X° and the XP movement approaches to word order variation within the DP.
Alexiadou, Artemis
core  

Home - About - Disclaimer - Privacy