Results 181 to 190 of about 6,562,448 (379)

Unraveling the Molecular Basis for G‐Quadruplex‐Binders to ALS/FTD‐Associated G4C2 Repeats of the C9orf72 Gene

open access: yesChemBioChem, EarlyView.
Some neurodegenerative disorders can be driven by recurrent mutations in the C9orf72 gene. These sequences can fold into G‐quadruplex secondary structures. Here, by performing in silico investigations coupled with FRET DNA melting assays, we unraveled the molecular basis for the selectivity of a series of organic and organometallic C9orf72 G4‐binders ...
Luisa D'Anna   +9 more
wiley   +1 more source

Deterring and Dissuading Nuclear Terrorism

open access: yesJournal of Strategic Security, 2012
While nuclear deterrence theory may be well-suited to dealing with nuclear-armed states, its suitability for deterring nuclear terrorism has frequently been questioned since 9/11.
John J. Klein
doaj  

Terrorism Prevention: A General Model [PDF]

open access: yes
In this paper, I present and discuss a method for modelling an important trade-off faced by terrorism prevention policies: the trade-off between, on the one hand, trying to reduce people's inclination towards terrorism, and, on the other hand, trying to ...
Franz Dietrich
core  

What if I fail? Examining the association between avoidance motivation and research career intentions

open access: yesThe Career Development Quarterly, EarlyView.
Abstract This study investigated how avoidance motivation, which entails a fear of failure and focus on avoiding negative outcomes, influences adolescents’ aspirations toward scientific research careers. Participants consisted of 245 high school students participating in a summer science enrichment program. Results of a hierarchical regression analysis
Eric D. Deemer   +3 more
wiley   +1 more source

Project management challenges in client‐consultant decision‐making: A case for the Ghanaian mining construction industry

open access: yesCanadian Journal of Administrative Sciences / Revue Canadienne des Sciences de l'Administration, EarlyView.
Abstract This study explores the complex decision‐making (DM) dynamics between clients and consultants, a crucial area often neglected in existing research. Utilizing a Multi‐Perspective Approach combined with Multi‐Criteria Decision Analysis, we examine DM challenges such as cost overruns, project delays, and compromised work quality stemming from ...
A. Akofa Amegboleza   +2 more
wiley   +1 more source

Corporate governance and the early disclosure of systematic risk

open access: yesCanadian Journal of Administrative Sciences / Revue Canadienne des Sciences de l'Administration, EarlyView.
Abstract Motivated by the need to understand firm characteristics associated with the disclosure of unexpected and unusual systematic risks, caused by events over which managers have little control, we examine the association between corporate governance and the early disclosure of such risks.
Abiodun S. Isiaka, Chima Mbagwu
wiley   +1 more source

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