Results 11 to 20 of about 90 (73)

Oxidative DNA Damage in Blood of CVD Patients Taking Detralex. [PDF]

Open Cardiovasc Med J, 2011
The main goal of the work reported here was to determine the degree of oxidative/alkali-labile DNA damages in peripheral blood as well as in the blood stasis from varicose vein of (chronic venous disorder) CVD patients. Moreover, determination of the impact of Detralex usage on the level of (oxidative) DNA damages in CVD patients was evaluated as well.
Krzyściak W, Cierniak A, Kózka M, Kozieł J.   +3 more
europepmc   +6 more sources

Comparative study of the pharmacological effects of Venarus Plus, Venarus, and Detralex on L-NAME-induced endothelial dysfunction, venous tone and platelet aggregation [PDF]

, 2020
In the present study we compared the pharmacological activity of Venarus Plus, Venarus and Detralex 1000 mg on the reversion of endothelial dysfunction (ED), and on the effect on venous tone, vascular permeability, and platelet aggregation.
Kolesnichenko, P. D., Gudyrev, O. S., Lukyanova, Y. S., Pokrovskaya, T. G., Gureev, V. V., Danilenko, L. M.   +5 more
core   +5 more sources

ვენოპროტექტორული მოქმედების პრეპარატის - დეტრალექსის მარკეტინგული კვლევა

EXPERIMENTAL & CLINICAL MEDICINE GEORGIA, 2023
 As of today, varicose veins occur in 10-40% of the working population of developed countries. The most effective means of managing this pathology is venoprotective drugs. The purpose of the research was the marketing analysis of the drug "Detralex",
ZARQUA, TEA, BERIDZE, MAIA, KEKELIDZE, IRINE   +2 more
core   +2 more sources

Atsitiktinės atrankos imčių tyrimas lyginant pirmo ir antro laipsnio hemorojaus gydymą perrišant guminiais žiedais su konservatyviu gydymu [PDF]

Lietuvos Chirurgija, 2008
Tomas Poškus1,  Kęstutis Strupas2 1 Vilniaus universiteto ligoninės Santariškių klinikų Centro filialo 3-iasis pilvo chirurgijos skyrius, Žygimantų g.
Tomas Poškus, Kęstutis Strupas
doaj   +2 more sources

Somatic Changes of Maternal High-Fat Diet on Offspring-Possible Deleterious Effects of Flavonoids? [PDF]

Nutrients
Background/Objectives: The rapidly increasing rate of obesity has become an extremely important public health problem, particularly in developed countries. Obesity is associated with a range of health problems, often referred to as the metabolic syndrome.
Ormindean CM, Ciortea R, Bucuri CE, Măluțan AM, Iuhas CI, Porumb CG, Nicula RL, Ormindean V, Roman MP, Nati ID, Suciu V, Florea A, Solomon C, Moldovan M, Mihu D.   +14 more
europepmc   +2 more sources

Biopharmaceutical and marketing evaluation of diosmin- and hesperidin-containing products on the Bulgarian market [PDF]

, 2019
Introduction Diosmin and hesperidin are commonly used flavonoids in the therapy of vascular diseases.AimThis study aimed to present an independent evaluation of the market status, quality and biopharmaceutical characteristics of diosmin- and hesperidin ...
Ivanova, Nadezhda Antonova; Medical University of Varna, Hyusein, Yozlem; Medical University of Varna, Slavov, Iliya Zhelev; Medical University of Varna, Kumanov, Ivo; Medical University of Varna   +3 more
core   +15 more sources

Comparative study of the pharmacological effects of Venarus Plus, Venarus, and Detralex on L-NAME-induced endothelial dysfunction, venous tone and platelet aggregation

, 2021
In the present study we compared the pharmacological activity of Venarus Plus, Venarus and Detralex 1000 mg on the reversion of endothelial dysfunction (ED), and on the effect on venous tone, vascular permeability, and platelet aggregation.
Pokrovskaya, Tatyana G., Sernov, Lev N., Kolesnichenko, Pavel D., Gudyrev, Oleg S., Lukyanova, Yulia S., Danilenko, Lyudmila M., Provotorov, Vladimir Y., Gureev, Vladimir V., Artyushkova, Elena B.   +8 more
core  

COMPARATIVE STUDY OF THE ORIGINAL TECHNOLOGY OF MICRONIZATION OF THE PURIFIED FLAVONOID FRACTION OF “DETRALEX®” AND THE TECHNOLOGY OF MICRONIZATION OF DRUGS D AND N OF THE UKRAINIAN MANUFACTURERS

Asian Journal of Pharmaceutical and Clinical Research, 2018
Objective: The objective of the study was to compare the degree of micronization of the bioflavonoid fraction (90% diosmin and 10% hesperidin) of different manufacturers which used for the treatment of the chronic venous insufficiency.Methods: “Detralex®,” medicines N and D, 500 mg coated tablets each were used as studied objects.
Igor Zupanets, Sergey Shebeko, Stanislav Zimin   +2 more
openaire   +2 more sources

Influence of the drug Detralex on calcium ion-dependent smooth muscle contractility, function of an endothelium and aggregation of thrombocytes in the conditions of experimental modeling of endothelial dysfunction [PDF]

, 2018
A venotonic effect was investigated after week administration of drug inside on model of the endoteliumdependent smooth muscle response to increased calcium ion isolated portal vein of rats.
Kolesnichenko, P. D., Hoshchenko, Y. A., Lukyanova, Y. S., Shutov, V. I., Povetkin, S. V.   +4 more
core  

Peculiarities of drug therapy of lower extremities chronic venous insufficiency

Амбулаторная хирургия, 2016
Chronic vein diseases (CVD) depending on the design and evaluation criteria of conducted epidemiologic studies are diagnosed in 20-85% of adult residents of industrially developed countries.
V. Y. Bogachev, B. V. Boldin, O. V. Dzhenina, V. N. Lobanov   +3 more
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