Results 181 to 190 of about 291,001 (382)

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Deuterium magnetic resonance imaging of tumors using low-dose systemic deuterated water labeling. [PDF]

Front Oncol
He M, Duzen JM, Larus T, Reavis H, Turowski SG, Feigin ME, Farthing DE, Spernyak JA, Buxbaum NP.   +8 more
europepmc   +1 more source

Investigations Into the Human Metabolism of Trestolone (7α‐Methyl‐19‐Nortestosterone)

Drug Testing and Analysis, EarlyView.
As the known metabolites of 7α‐methyl‐19‐nortestosterone (MENT), M1 and M2, suffer from chromatographic issues under routine doping control conditions, the human metabolism of MENT was reinvestigated. From the numerous new metabolites detected, especially, M5 and M10 were identified as the most promising candidates to be implemented into routine ...
Thomas Piper, Gregor Fusshöller, Mario Thevis   +2 more
wiley   +1 more source

Explaining deuterium-depleted water as a cancer therapy: a narrative review. [PDF]

Eur J Cancer Prev
Kyriakopoulos AM, Seneff S.
europepmc   +1 more source

Deuterium Isotope Effects in the Photocycle Transitions of the Photoactive Yellow Protein [PDF]

, 2003
Johnny Hendriks, Ivo H. M. van Stokkum, Klaas J. Hellingwerf   +2 more
openalex   +1 more source

A Mucoadhesive Hydrogel for Precise Resveratrol Delivery in the Management of Inflammatory Bowel Disease

Food Frontiers, EarlyView.
CMTR‐Gel targeting to the inflamed mucosa by electrostatic interactions. ABSTRACT Natural drug‐food homology compounds have vast therapeutic potential, particularly for inflammatory bowel disease (IBD), but their poor water solubility, instability, and limited mucosal availability hinder their clinical translation.
Wenqiu Xu, Xiaojia Lv, Jilun Ye, Ying Li, Hua Yu, Chenyang Li, Haiqiang Wu, Wei Xiong   +7 more
wiley   +1 more source

Pushing the limits of hydrogen/deuterium exchange mass spectrometry to study protein:fragment low affinity interactions. [PDF]

Commun Chem
F Malta C, O Silva D, Grädler U, M F Sousa P, Musil D, Schwarz D, Bomke J, M Bandeiras T, Bortoluzzi A.   +8 more
europepmc   +1 more source

Pulsed Hydrogen–Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer’s Disease Mutants

, 2021
Eva Illes‐Toth, Georg Meisl, Don L. Rempel, Tuomas P. J. Knowles, Michael L. Gross   +4 more
openalex   +2 more sources

Guidelines for Sample Preparation and Stable Isotope Analysis of Food for Traceability Studies

Food Safety and Health, EarlyView.
This workflow illustrates sample preparation and analysis steps in stable isotope ratio mass spectrometer (IRMS) for food traceability. It emphasizes standardized preparation, encapsulation, calibration, and quality control to ensure accurate, comparable isotope data critical for verifying food origin and authenticity across complex supply chains ...
Bayan Nuralykyzy, Syed Abdul Wadood, Jing Nie, Hanyi Mei, Shengzhi Shao, Yongzhi Zhang, Chunlin Li, Yuwei Yuan, Karyne M. Rogers   +8 more
wiley   +1 more source

Gene Expression Patterns in Lung Adenocarcinoma Cells in Response to Changes in Deuterium Concentration. [PDF]

Int J Mol Sci
Csonka GI, Papp A, Somlyai I, Somlyai G.
europepmc   +1 more source