Results 11 to 20 of about 275,445 (328)
Deuterium in drug discovery: progress, opportunities and challenges
Nature Reviews Drug Discovery, 2023 Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one neutron to a molecule. Despite being a subtle change, this structural modification, known as deuteration, may improve the pharmacokinetic and/or toxicity profile
Rita Maria Concetta Di Martino +2 more
exaly +2 more sources
Hyperfine Interactions, 2010 The strong interaction shift and broadening in pionic deuterium have been remeasured with high statistics by means of the (3p-1s) X-ray transition using the cyclotron trap and a high-resolution crystal spectrometer.
Amaro, F. D. +18 more
core +15 more sources
Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules
Chemical Reviews, 2022 Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas, from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by deuterium gives rise to improved absorption, distribution, metabolism, and
Sara Kopf, Florian Bourriquen, Wu Li
exaly +2 more sources
Influence of the presence of deuterium on displacement damage in tungsten
Nuclear Materials and Energy, 2018 The influence of the presence of deuterium on displacement damage in tungsten is studied by implanting 20 MeV tungsten ions into displacement-damaged tungsten already containing 1.7 at.% deuterium.
T. Schwarz-Selinger +3 more
doaj +2 more sources
Spectral tracing of deuterium for imaging glucose metabolism. [PDF]
Nature Biomedical Engineering, 2019 Cells and tissues often display pronounced spatial and dynamical metabolic heterogeneity. Common glucose-imaging techniques report glucose uptake or catabolism activity, yet do not trace the functional utilization of glucose-derived anabolic products ...
Liu, Yinong +7 more
core +2 more sources
Chemical Reviews, 2021 Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is a widespread tool for structural analysis across academia and the biopharmaceutical industry.
Ellie I. James +4 more
semanticscholar +1 more source
The JET hybrid scenario in Deuterium, Tritium and Deuterium-Tritium
Nuclear Fusion, 2023 The JET hybrid scenario has been developed from low plasma current carbon wall discharges to the record-breaking Deuterium-Tritium plasmas obtained in 2021 with the ITER-like Be/W wall.
J. Hobirk +108 more
semanticscholar +1 more source
Deuterium metabolic imaging - Back to the future.
Journal of magnetic resonance (San Diego, Calif. 1997 : Print), 2021 Deuterium metabolic spectroscopy (DMS) and imaging (DMI) have recently been described as simple and robust MR-based methods to map metabolism with high temporal and/or spatial resolution.
Henk M. de Feyter, R. D. de Graaf
semanticscholar +1 more source
Primordial Deuterium after LUNA: concordances and error budget [PDF]
Journal of Cosmology and Astroparticle Physics, 2020 The accurate evaluation of the nuclear reaction rates and corresponding uncertainties is an essential requisite for a precise determination of light nuclide primordial abundances.
O. Pisanti +3 more
semanticscholar +1 more source