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Applications of Deuterium in Medicinal Chemistry.
Journal of Medicinal Chemistry, 2019The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA has recently approved the first deuterium-labeled drug. Precision deuteration goes beyond the pure and simple amelioration of the pharmacokinetic parameters of a ...
T. Pirali +3 more
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Space Science Reviews, 1999
Deuterium fractionations in cometary ices provide important clues to the origin and evolution of comets. Mass spectrometers aboard spaceprobe Giotto revealed the first accurate D/H ratios in the water of Comet 1P/Halley. Ground-based observations of HDO in Comets C/1996 B2 (Hyakutake) and C/1995 O1 (Hale-Bopp), the detection of DCN in Comet Hale-Bopp ...
R, Meier, T C, Owen
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Deuterium fractionations in cometary ices provide important clues to the origin and evolution of comets. Mass spectrometers aboard spaceprobe Giotto revealed the first accurate D/H ratios in the water of Comet 1P/Halley. Ground-based observations of HDO in Comets C/1996 B2 (Hyakutake) and C/1995 O1 (Hale-Bopp), the detection of DCN in Comet Hale-Bopp ...
R, Meier, T C, Owen
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Burn performance of deuterium-tritium, deuterium-deuterium, and catalyzed deuterium ICF targets
Nuclear Fusion, 1983The University of Illinois hydrodynamic burn code, AFBURN, has been used to model the performance of homogeneous D-T, D2, and catalyzed deuterium ICF targets. Yields and gains are compared for power-producing targets. AFBURN is a one-dimensional, two-temperature, single-fluid hydrodynamic code with non-local fusion product energy deposition.
D.B. Harris, T.E. Blue
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Angewandte Chemie, 2020
Precise deuterium incorporation with controllable deuterated sites and amount is extremely desirable. Here, a facile and efficient electrocatalytic deuterodehalogenation of halides using heavy water (D 2 O) as the deuteration reagent and electrochemical ...
Cuibo Liu +4 more
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Precise deuterium incorporation with controllable deuterated sites and amount is extremely desirable. Here, a facile and efficient electrocatalytic deuterodehalogenation of halides using heavy water (D 2 O) as the deuteration reagent and electrochemical ...
Cuibo Liu +4 more
semanticscholar +1 more source
ChemSusChem, 2020
Motivated by the problem of energy shortage and in view of current efforts to develop clean, renewable energy sources based on fusion, we propose a solar-driven strategy for deuterium evolution. Deuterium is a critical resource for many aspects; however,
Gongchang Zeng +9 more
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Motivated by the problem of energy shortage and in view of current efforts to develop clean, renewable energy sources based on fusion, we propose a solar-driven strategy for deuterium evolution. Deuterium is a critical resource for many aspects; however,
Gongchang Zeng +9 more
semanticscholar +1 more source
Nuclear Physics B - Proceedings Supplements, 2000
The knowledge of the primordial deuterium to hydrogen ratio provides one of the most reliable tests of the early Universe nucleosynthesis models and a direct estimate of the cosmic baryon density. Evaluations have been traditionally made using D/H estimations in the interstellar medium, extrapolated backwards in time with the use of galactic evolution ...
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The knowledge of the primordial deuterium to hydrogen ratio provides one of the most reliable tests of the early Universe nucleosynthesis models and a direct estimate of the cosmic baryon density. Evaluations have been traditionally made using D/H estimations in the interstellar medium, extrapolated backwards in time with the use of galactic evolution ...
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Contemporary hydrogen deuterium exchange mass spectrometry.
Methods, 2018Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) emerged as a tool for biochemistry and structural biology around 25 years ago. It has since become a key approach for studying protein dynamics, protein-ligand interactions, membrane proteins and ...
Irina Oganesyan +2 more
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Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals
The Annals of Pharmacotherapy, 2018Objective: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
E. Russak, Edward M. Bednarczyk
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Plasma Temperature Inference from Deuterium-Tritium/Deuterium-Deuterium Neutron Discrimination
Nuclear Science and Engineering, 2015AbstractDeuterium-deuterium and deuterium-tritium reaction rates may be compared to determine plasma temperatures in the 10- to 200-eV range. Distinguishing neutrons from these two reactions is difficult when yields are low or unpredictable. Time-of-flight (TOF) methods fail if the source is extended in time. These neutrons may be distinguished because
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Deuterium NQR in samples dilute in deuterium
Journal of Magnetic Resonance (1969), 1978Abstract To demonstrate its high sensitivity in the detection of the nuclear quadrupole resonance of deuterium, double resonance with continuous coupling (D RC C) is used to obtain the spectrum of formic acid with deuterium present only in natural (0.0156%) abundance.
D.T Edmonds, J.P.G Mailer
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