Results 311 to 320 of about 291,001 (382)

Deuterium in drug discovery: progress, opportunities and challenges

Nature Reviews Drug Discovery, 2023
Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one neutron to a molecule. Despite being a subtle change, this structural modification, known as deuteration, may improve the pharmacokinetic and/or toxicity profile
Rita Maria Concetta Di Martino, Brad D Maxwell, Tracey Pirali   +2 more
exaly   +2 more sources

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Nature Methods, 2019
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems.
Glenn R Masson, John E Burke, Natalie G Ahn   +2 more
exaly   +2 more sources

Deuterium‐ and Tritium‐Labelled Compounds: Applications in the Life Sciences

Angewandte Chemie - International Edition, 2018
Volker Derdau, William J Kerr, Marc Reid
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

The baryon density of the Universe from an improved rate of deuterium burning

Nature, 2020
Francesca Cavanna, Federico Ferraro, Marialuisa Aliotta   +2 more
exaly   +2 more sources

Stem water cryogenic extraction biases estimation in deuterium isotope composition of plant source water

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Stem xylem uptake and transport of plant source water is widely considered a critical component of the global water cycle. The deuterium signature of cryogenically extracted plant stem water (δ2Hstem_CVD) provides a useful means for studying
Yongle Chen, Brent R Helliker, Xianhui Tang   +2 more
exaly   +2 more sources

Applications of Deuterium in Medicinal Chemistry

Journal of Medicinal Chemistry, 2019
The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA has recently approved the first deuterium-labeled drug. Precision deuteration goes beyond the pure and simple amelioration of the pharmacokinetic parameters of a ...
Tracey Pirali, Marta Serafini, Sarah Cargnin   +2 more
exaly   +2 more sources

Deuterium metabolic imaging of the human brain in vivo at 7 T

Magnetic Resonance in Medicine, 2022
To explore the potential of deuterium metabolic imaging (DMI) in the human brain in vivo at 7 T, using a multi‐element deuterium (2H) RF coil for 3D volume coverage.
Eulalia Serés Roig, Henk M. de Feyter, T. Nixon, L. Ruhm, A. Nikulin, K. Scheffler, N. Avdievich, A. Henning, R. D. de Graaf   +8 more
semanticscholar   +1 more source

Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo

Science Advances, 2018
DMI shows metabolism of acetate and glucose in the brain and liver and reveals the Warburg effect in patients with brain tumors. Currently, the only widely available metabolic imaging technique in the clinic is positron emission tomography (PET ...
Henk M De Feyter, Kevin L Behar, Zachary A Corbin   +2 more
exaly   +2 more sources

Laser spectroscopy of muonic deuterium

Science, 2016
Randolf Pohl, François Nez, Luis M P Fernandes   +2 more
exaly   +2 more sources

Cometary Deuterium

Space Science Reviews, 1999
Deuterium fractionations in cometary ices provide important clues to the origin and evolution of comets. Mass spectrometers aboard spaceprobe Giotto revealed the first accurate D/H ratios in the water of Comet 1P/Halley. Ground-based observations of HDO in Comets C/1996 B2 (Hyakutake) and C/1995 O1 (Hale-Bopp), the detection of DCN in Comet Hale-Bopp ...
R, Meier, T C, Owen
openaire   +2 more sources