Results 111 to 120 of about 273,322 (239)

Recent advances in catalytic α-deuteration of carbonyl compounds

Tetrahedron Chem
Deuterium-labeled compounds are increasingly important in synthetic chemistry, pharmaceutical science, and materials research owing to the unique effects of isotopic substitution on molecular properties and metabolic stability.
Kensuke Masui, Takashi Ohshima, Ryo Yazaki   +2 more
doaj   +1 more source

Unraveling the Importance of Surface Hydrogen Diffusion in Photocatalysis by Isotope Probing

Angewandte Chemie International Edition, EarlyView.
Surface hydrogen diffusion on titanium dioxide is identified as a crucial step in photocatalytic hydrogen evolution. Demonstrated by deuterium substitution in methanol, restricted diffusion to the co‐catalyst leads to hindered formation of molecular hydrogen and a high KIE.
Philip Petzoldt, Sonia Mackewicz, Lucia Mengel, Martin Elsner, Martin Tschurl, Ueli Heiz   +5 more
wiley   +1 more source

Cobalt-catalyzed hydrothiolation of alkynes for the diverse synthesis of branched alkenyl sulfides

Nature Communications
Alkenyl sulfides have gained increasing prominence in medicinal chemistry and materials. Hydrothiolation of alkynes for the diverse synthesis of alkenyl sulfides is an appealing method.
Jiale Ying, Yan Tan, Zhan Lu
doaj   +1 more source

A confocal Raman microscopic visualization of small penetrants in cellulose acetate using a deuterium-labeling technique. [PDF]

Sci Rep, 2020
Kubota H, Sakamoto K, Matsui T.
europepmc   +1 more source

Absorption, distribution, metabolism and excretion of londamocitinib after single‐dose inhaled, intravenous and oral administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff, Peter Bold, Maria Heijer, Ryan A. Bragg, Danielle Steele, Tina Jellesmark Jensen, Davinder P. S. Dosanjh, Sabrina I. Hanswijk‐Bartelds, Esther van Duijn, Elwin R. Verheij, Somasekhara Menakuru, Rod Hughes, Helena Dahlbäck   +12 more
wiley   +1 more source

Silver‐Mediated Deuterium Labelling of Quinones and Related Compounds by Hydrogen Isotope Exchange With D2O

Chemistry – A European Journal, EarlyView.
A new silver‐catalyzed H/D exchange reaction was developed for the labelling of quinones and related compounds. Both homogeneous and heterogeneous catalytic processes were implemented using heavy water as a simple deuterium source. The corresponding deuterated compounds were obtained with high isotopic enrichment through a practical method that opens ...
Joyce C. de Oliveira, Mateus P. Nunes, Frédéric Miserque, Valérie Geertsen, Guilherme A. M. Jardim, Eric Doris, Eufrânio N. da Silva Júnior, Edmond Gravel   +7 more
wiley   +1 more source

Synthesis and Characterization of Stable Isotope Labeled 3,3',4,4'-Tetrachlorobiphenyl-D6

Journal of Isotopes
A new synthetic method of the stable isotope labeled 3,3',4,4'-tetrachlorobiphenyl-D6 was investigated. The synthesis of 3,3',4,4'-tetrachlorobiphenyl-D6 is based on 1,2-dichlorobenzene-D4 as the labeling precursor through three steps of catalyzed ...
Rong WANG, Hui GUO, Wulian CHEN
doaj   +1 more source

Live-Cell Imaging and Quantification of PolyQ Aggregates by Stimulated Raman Scattering of Selective Deuterium Labeling. [PDF]

ACS Cent Sci, 2020
Miao K, Wei L.
europepmc   +1 more source

Persilylated and Related Silyl Anion‐Induced Synthesis of Group 3–10 Metal–Silyl Complexes

Chemistry – A European Journal, EarlyView.
Persilylated and related silyl anions serve as powerful tools for constructing metal–silyl complexes across group 3–10 elements. Their strong σ‐donating ability and steric bulk stabilize low‐coordinate, reactive species and enable unique bonding motifs.
Yusuke Sunada
wiley   +1 more source

An Algorithm for the Deconvolution of Mass Spectrosopic Patterns in Isotope Labeling Studies. Evaluation for the Hydrogen−Deuterium Exchange Reaction in Ketones

, 2016
An easy to use computerized algorithm for the determination of the amount of each labeled species differing in the number of incorporated isotope labels based on mass spectroscopic data is described and evaluated.
Gustav Oberdorfer (726095), Wolfgang Kroutil (1279629), Jennifer M. Kremsner (1264197), C. Oliver Kappe (1264179), Christian C. Gruber (2413288), Constance V. Voss (2413291)   +5 more
core   +1 more source