Results 141 to 150 of about 273,322 (239)

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Side-chain-selective deuterium labeling by a simple bio-expression method enhances resolution and simplifies spectra in ¹H-detected protein solid-state NMR. [PDF]

J Biomol NMR
Shigemitsu Y, Miyazaki Y, Terami H, Ostapova D, Matsunaga T, Takahashi R, Inoue T, Yamazaki T, Ishii Y.   +8 more
europepmc   +1 more source

A generalizable method for the purification and biophysical characterization of bacterial membrane receptors. [PDF]

Protein Sci
Abstract Membrane‐embedded bacterial receptors are challenging to express and purify in soluble form, yet their isolated domains are essential tools for structural and ligand‐discovery studies. Pseudomonas aeruginosa relies on the TonB‐dependent heme receptor HasR for iron acquisition, a process central to its pathogenicity.
Bosetto F, Zacharopoulou M, Bycroft M, Kish M, Zinzalla G, Rowling PJE, McLaughlin SH, Phillips JJ, Itzhaki LS, Mela I.   +9 more
europepmc   +2 more sources

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source

Should the United States Regulate Mandatory Labeling for Genetically Modified Foods? [PDF]

Public debate continues over whether the United States should regulate genetically modified (GM) foods by imposing a mandatory labeling policy. This paper develops a model that shows that a voluntary GM-labeling policy results in higher welfare than a ...
Huffman, Wallace, Tegene, Abebayehu, Rousu, Matthew, Shogren, Jason F.   +3 more
core  

Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner

Small, EarlyView.
Polyion complex micelles composed of blends of ABA and AB block copolymers can form coacervates with a hexagonally packed cylinder nanostructure after heating. The resulting coacervates can release the micelles under physiological conditions in a zero‐order kinetics, possessing cargo proteins.
Takumi Egashira, Hiroshi Kamizawa, Yujiro Hamada, Wataru Fushimoto, Hiroshi Y. Yoshikawa, Yuji Higaki, Atsushi Takahara, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura   +9 more
wiley   +1 more source

Uncovering Backbone Conformation for Rigid DPP-Based Donor-Acceptor Conjugated Polymer Using Deuterium Labeling and Neutron Scattering. [PDF]

Macromolecules
Cao Z, Li Z, Mooney M, Do C, Hong K, Rondeau-Gagné S, Xia W, Gu X.   +7 more
europepmc   +1 more source

Beef Labeling After BSE: Do Consumers Care about BSE Testing and GMO Labeling? Evidence from Canada and the US [PDF]

Following the May 2003 Canadian BSE case, food safety issues have become even more prominent to policymakers and consumers. In both Canada and the US, governments and industry have responded with a variety of quality assurance, traceability and labeling ...
Yang, Jun, Steiner, Bodo E.
core  

Quantitative Imaging of Water Diffusion in Brain Parenchyma at Cellular Resolution Using Stimulated Raman Scattering Microscopy

Small, EarlyView.
A multimodal multiphoton imaging framework enables high‐resolution quantification of water diffusion in brain tissue. By tracking deuterated water via stimulated Raman scattering (SRS) microscopy, this study resolves the microscopic heterogeneity of water diffusion at cellular resolution and determines apparent diffusion coefficients in health and ...
Wakana Ozaki, Ayano Suzuki, Satoshi Ii, Masato Yasui, Mutsuo Nuriya   +4 more
wiley   +1 more source

Resolving Conflicting Mechanisms for Photoredox Allylic sp³-CH Arylation Using Deuterium-Labeling and Isotope Effects. [PDF]

ACS Catal
Dagar A, Das T, Mallojjala SC, Hirschi JS, Vetticatt MJ.   +4 more
europepmc   +1 more source