Results 171 to 180 of about 273,322 (239)

Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?

Experimental Physiology, EarlyView.
Abstract Understanding the turnover of proteins in tissues gives information as to how external stimuli result in phenotypic change. Nowhere is such phenotypic change more conspicuous than skeletal muscle, which can be effectively remodelled by increased loading, ageing and unloading (disuse), all of which are subject to modification by nutrition and ...
Changhyun Lim, James McKendry, Matthew Lees, Philip J. Atherton, Nicholas A. Burd, Andrew M. Holwerda, Luc J. C. van Loon, Chris McGlory, Cameron J. Mitchell, Kenneth Smith, Daniel J. Wilkinson, Tanner Stokes, Stuart M. Phillips   +12 more
wiley   +1 more source

Rh/Ru-Catalyzed Asymmetric One-Pot Sequential Hydrogenation: Stereodivergent Synthesis of Chiral 1,3-Amino Alcohol Derivatives. [PDF]

JACS Au
He J, Luo Y, Li W, Liu D, Zhang W.
europepmc   +1 more source

Applying lessons from limb muscle disuse and ageing to better understand ventilator‐induced diaphragm dysfunction

Experimental Physiology, EarlyView.
Abstract Mechanical ventilation (MV) is a life‐saving intervention applied to critically ill patients. A common consequence of MV is ventilator‐induced diaphragm dysfunction (VIDD), which is characterized by significant diaphragm atrophy and reduced contractile function. Older patients who receive MV are more likely to develop VIDD, have worse recovery,
P. H. C. Mesquita, J. L. Halle, J. D. Fuqua, B. F. Miller   +3 more
wiley   +1 more source

Synthesis of deuterated ALC-0315 for contrast variation SANS analysis of lipid nanoparticles. [PDF]

RSC Adv
Zhang HH, Leite W, Pingali SV, Nusser B, Urban VS, O'Neill H.   +5 more
europepmc   +1 more source

Simultaneously Quantitative Analysis of Naringin and Its Major Human Gut Microbial Metabolites Naringenin and 3-(4'-Hydroxyphenyl) Propanoic Acid via Stable Isotope Deuterium-Labeling Coupled with RRLC-MS/MS Method. [PDF]

Molecules, 2019
Chen T, Wu H, He Y, Pan W, Yan Z, Liao Y, Peng W, Gan L, Zhang Y, Su W, Yao H.   +10 more
europepmc   +1 more source

Resistance training load does not determine resistance training‐induced hypertrophy across upper and lower limbs in healthy young males

The Journal of Physiology, EarlyView.
Abstract figure legend In healthy young males, we found that skeletal muscle hypertrophy following a period of resistance exercise training (RET) was consistent within and between subjects, as assessed using a variety of established methods. The skeletal muscle hypertrophic response was independent of external load.
Matthew J. Lees, Jonathan C. Mcleod, Robert W. Morton, Brad S. Currier, Matthew D. Fliss, Sean R. McKellar, Rajbir S. Sidhu, Ben N. Stansfield, Erin K. Webb, Chris McGlory, Jatin G. Burniston, Stuart M. Phillips   +11 more
wiley   +1 more source

Water-Dispersible Ruthenium Nanocatalyst for Carbonyl Reduction With D₂ or T₂ in Aqueous Media. [PDF]

Angew Chem Int Ed Engl
Martinelli E, Jiménez Rioboo R, Weck R, Feuillastre S, Martínez-Prieto LM, Pieters G, Derdau V.   +6 more
europepmc   +1 more source

Non‐steady‐state modelling reveals reduced skeletal muscle protein synthesis as the primary driver of disuse‐atrophy in young, healthy females

The Journal of Physiology, EarlyView.
Abstract figure legend We used a unilateral model of divergent contractile stimuli, in which one leg was subjected to 10 days of unloading and the contralateral leg was simultaneously subjected to loading. We examined how accounting for changes in protein pool size, using steady‐state and non‐steady‐state modelling approaches, impacted rates of muscle ...
Callum J. Pufahl, Jonathan C. Mcleod, Emily J. Ferguson, Kristine Boileau, Brendan Ross, Thomas R. Tripp, Jennifer A. Wilkinson, Craig A. Simpson, Brendon J. Gurd, Chris McGlory   +9 more
wiley   +1 more source

Implementation of Nano Flow Chromatography Coupled to Mass Spectrometry as a Reliable and Sensitive Discovery Lipidomics Platform

Rapid Communications in Mass Spectrometry, Volume 40, Issue 23, 15 December 2026.
ABSTRACT Rationale Untargeted lipidomics is commonly performed at analytical flow rates, which consume more solvent and may require higher on‐column sample loads when sensitivity is limited by analyte abundance. Nano flow separations use lower flow rates and sample loads, reducing solvent consumption and facilitating improved electrospray ionization ...
Ciara J. Sallowicz, Thiago Mattos, Rahul R. Deshpande, Bashar Amer, Susan S. Bird   +4 more
wiley   +1 more source

Cis–Trans Rotational Isomerism of Formic Acid, Sulfur, and Selenium Analogues and Their Dimers: Chemical Kinetics Under Interstellar Conditions

International Journal of Chemical Kinetics, Volume 58, Issue 12, Page 1136-1145, December 2026.
ABSTRACT We present chemical kinetic rate constants for the cis to trans isomerisation or rotamerization of monomeric seleno‐, thio‐, and formic acids and that of three of their dimeric species, based on variational transition state theory and multidimensional tunneling calculations in the gas‐phase, from 10 K to 300 K. These provide, firstly, reliable
Judith Wurmel, John M. Simmie
wiley   +1 more source