Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Impact of GDP Information Technology in Developing of Regional Central Business (Case 50 Airports IT City Development in Indonesia) [PDF]
, 2017 Joko Suyono +4 more
openalex +1 more source
Changing Microcircuits in the Subplate of the Developing Cortex [PDF]
, 2012 Sarada Viswanathan +3 more
openalex +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS [PDF]
, 2011 Hui Wang +4 more
openalex +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reduction of monoclonal antibody viscosity using interpretable machine learning
mAbsEarly identification of antibody candidates with drug-like properties is essential for simplifying the development of safe and effective antibody therapeutics.
Emily K. Makowski +10 more
doaj +1 more source
Developing a Public Interest Mandate for the Governance and Use of Administrative Data in the United Kingdom [PDF]
, 2016 Graeme Laurie, Leslie Stevens
openalex +1 more source