Results 191 to 200 of about 14,908,548 (354)

A novel throughput assay to assess molecular hydrophobicity during early biotherapeutic developability assessments. [PDF]

MAbs
Crames M, Davis M, Marlow MS.
europepmc   +1 more source

MEASURES TO DEVELOP AND INCREASE THE PRODUCTIVITY OF VINEYARDS IN UZBEKISTAN

, 2022
B.Umarov Q.Ahmadov M.Oqilova
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A droplet microfluidics-based platform for generating target-specific, natively-paired immune libraries and identifying potent and developable antibodies. [PDF]

Sci Rep
Ramasubramanian A, Deveney BT, Clark SA, Boutin P, Keepseagle K, Riahi S, Lao T, Salemi M, Kathuria S, Amengual-Rigo P, Dimova D, Marcovici L, Hopke J, Newton J, Mix K, Kramer K, Erasimus H, Furtmann N, Mottet G, Suslov N, Mahendra A, Pemmaraju SR, Chowdhury PS, Weitz DA, Heyman JA.   +24 more
europepmc   +1 more source

TEACHİNG TURKİSH AS A FOREİGN LANGUAGE DEVELOPİNG READİNG SKİLLS OF UZBEK TURKS

, 2023
Zebo Fazliddinova
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Engineering oriented shape optimization of GHT-Bézier developable surfaces using a meta heuristic approach with CAD/CAM applications. [PDF]

Sci Rep
BiBi S, Misro MY, Abbas M, Birhanu A, Miura KT, Wahab MNA, Mahmoud EE.   +6 more
europepmc   +1 more source

Privacy and Big Data: The Need for a Multi-Stakeholder Approach for Developing an Appropriate Privacy Regulation in the Age of Big Data

, 2015
Matthias Georg Will
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

From discovery to the clinic: structural insights, engineering options, clinical, and 'next wave' applications of camelid-derived single-domain antibodies. [PDF]

MAbs
Evers A, Guarnera E, Pekar L, Zielonka S.   +3 more
europepmc   +1 more source