Results 281 to 290 of about 14,908,548 (354)

Enhancing polyreactivity prediction of preclinical antibodies through fine-tuned protein language models. [PDF]

open access: yesJ Pharm Anal
Zhou Y   +8 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Editorial: Progress and challenges in computational structure-based design and development of biologic drugs

open access: yesFrontiers in Molecular Biosciences
Traian Sulea   +2 more
doaj   +1 more source

Technological advancements in antibody-based therapeutics for treatment of diseases. [PDF]

open access: yesJ Biomed Sci
Lu RM   +14 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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