Results 61 to 70 of about 925,172 (288)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Improving the efficiency of software development for unmanned systems using a simulation environment

Adaptivni Sistemi Avtomatičnogo Upravlinnâ
This article discusses tools and approaches to improve the efficiency of software development in terms of development cycle time. It is important to take into account the factors of preserving the physical integrity of unmanned systems by using a ...
А. Ахаладзе, І. Ахаладзе   +1 more
doaj   +1 more source

Regularization Algorithms for Linear Copositive Programming Problems: An Approach Based on the Concept of Immobile Indices

Algorithms, 2022
In this paper, we continue an earlier study of the regularization procedures of linear copositive problems and present new algorithms that can be considered as modifications of the algorithm described in our previous publication, which is based on the ...
Olga Kostyukova, Tatiana Tchemisova
doaj   +1 more source

Development of New Algorithms for High Frequency Electromagnetic Scattering

Computer Modeling in Engineering & Sciences, 2004
We describe elements of our current work on the development of new methods for high frequency electromagnetic scattering, based on the wavefront (WF) representation of propagating fields and on the asymptotic but rigorous solution of integral equations for surface currents.
Bleszynski, E., Bleszynski, M., Jaroszewicz, T.   +2 more
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Automated Proving Properties of Expectation-Maximization Algorithm using Symbolic Tools [PDF]

Telfor Journal, 2012
In many analyses based on estimating the parameters of probability distribution functions, the algorithms are developed for unknown probabilities. Some algorithms are derived starting from previous solutions and algorithms.
M. Lutovac, V. Mladenovic, M. Lutovac
doaj  

LIFO-Backpressure Achieves Near Optimal Utility-Delay Tradeoff

, 2011
There has been considerable recent work developing a new stochastic network utility maximization framework using Backpressure algorithms, also known as MaxWeight.
Huang, Longbo, Krishnamachari, Bhaskar, Moeller, Scott, Neely, Michael J.   +3 more
core   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source