Bioinformatic Analysis and Molecular Docking Identify Isorhamnetin Is a Candidate Compound in the Treatment of Pulmonary Artery Hypertension. [PDF]
Shao C, Xia W, Liu Y.
europepmc +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson+11 more
wiley +1 more source
Reinventing the regions: Victoria’s changing regional economies [PDF]
Regional Victoria accounts for around a quarter of the State\u27s population and economic output. In March 2013 Deputy Premier and Minister for Regional and Rural Development Peter Ryan released the Reinventing the Regions report which documents the
Committee for Economic Development of Australia+1 more
core
The influence of digital professional development and professional learning communities in the relationship between school digital preparedness and digital instructional integration. [PDF]
Amemasor SK+4 more
europepmc +1 more source
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu+11 more
wiley +1 more source
Statistical testing and spatio-temporal evolution characteristics of the coupling coordination between green agricultural production efficiency and food security. [PDF]
Li T, Hu Y.
europepmc +1 more source
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani+14 more
wiley +1 more source
Bridging early medical education and health systems improvement: a multi-faceted faculty development program to enhance engagement and impact. [PDF]
Lau CY+4 more
europepmc +1 more source