Results 61 to 70 of about 32,083,256 (335)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Landscape, environment and community impacts of nuclear power [PDF]
, 2012 This paper is the third in a series of 8 that make up the evidence base for SDC report 'The role of nuclear power in a low carbon economy'.This document investigates the landscape impacts of all the processes involved in nuclear power from mining the ...
Sustainable Development Commission
core
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Cambodia’s New Technical and Vocational Education and Training Policy [PDF]
, 2018 Key Points: Cambodia’s demographic divident offers great opportunities, but its human resource base remains largely low-skilled. It will be critical for Cambodia not only to improve education and technical and vocational training for young people ...
Asian Development Bank
core +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Gender Equality and Social Inclusion Assessment of the Energy Sector: Enhancing Social Sustainability of Energy Development in Nepal [PDF]
, 2018 In Nepal, deeply embedded structural conditions determined by gender, caste or ethnicity, religion, language, and even geography have made access to and benefits from energy resources highly uneven.
Asian Development Bank
core +1 more source
Holistic Integrative Medicine Declaration [PDF]
Zhongguo quanke yixueHolistic integrative medicine, abbreviated as HIM, has been officially proposed since 2012. Its theoretical system has been continuously improved, and its practical methods have become increasingly diverse, becoming an inevitable choice and path for the ...
China Institute for Development Strategy of Holistic Integrative Medicine
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Securing good health for the whole population (Wanless Review) : submission from the SDC [PDF]
, 2012 The Sustainable Development Commission fully supports the terms of reference contained in the document 'Securing good health for the whole population : final report'.
Sustainable Development Commission
core
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source