Results 251 to 260 of about 3,560,489 (356)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

'Being empathetic to my patients and ourselves': a qualitative process evaluation of READ-Y psychological first aid training for healthcare workers working in routine care. [PDF]

Eur J Psychotraumatol
Wang L, Li X, Qiu C, Wang J, Zeng L, Liu T, Zhong Z, Wu Y, Xu L, Liu Y, Leamy M, Hu M.   +11 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Decision-Making Process of Healthcare Providers Regarding Catheterization Method: A Nationwide Survey Study. [PDF]

Neurourol Urodyn
Christiaans CHH, van Veen FEE, Scheepe JR, Blok BFM.   +3 more
europepmc   +1 more source

LLM-AID: Leveraging Large Language Models for Rapid Domain-Specific Accelerator Development [PDF]

Farshad Firouzi, Sri Sai Rakesh Nakkilla, Chh Fu, Sanmitra Banerjee, Jonti Talukdar, Krishnendu Chakrabarty   +5 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Fully closed-loop systems: can people with type 1 diabetes just do it? Insights from open-source systems. [PDF]

Diabetologia
Lal R, Braune K, Lewis DM, Petruzelkova L, de Bock M, Hussain S.   +5 more
europepmc   +1 more source

Malaysia’s Economic Growth: Evidence from Japan-Malaysia Bilateral Trade and Development Aid Relationships

Ahmad Fiqry Ahmad Murad, Abdul Hafizh Mohd Azam, Muhamad Rias K. V. Zainuddin   +2 more
openalex   +2 more sources

E-tool for improving vaginal health care Development and evaluation of an electronic decision aid for self-diagnosis and treatment in General Practice in the Netherlands. [PDF]

C.M. van der Heijde, Merel Hoek, Peter Vonk   +2 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source