Results 91 to 100 of about 1,175,687 (245)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Association between Development Assistance for Health and Disease Burden: A Longitudinal Analysis on Official Development Assistance for HIV/AIDS, Tuberculosis, and Malaria in 2005-2017. [PDF]

Int J Environ Res Public Health, 2022
Kim S, Tadesse E, Jin Y, Cha S.
europepmc   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Development assistance for human resources for health, 1990-2020. [PDF]

Hum Resour Health, 2022
Micah AE, Solorio J, Stutzman H, Zhao Y, Tsakalos G, Dieleman JL.   +5 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

FEATURES OF FIRST-GRADERS’ ADAPTATION TAKING INTO ACCOUNT THE INDIVIDUAL TYPOLOGICAL INDICATORS AND SIGNS OF DEVELOPMENT DEFICIENCIES

Вестник Кемеровского государственного университета, 2015
An experimental investigation of physiological parameters of the central nervous system and the adaptation of firstgraders with different development deficiencies was performed.
N. P. Krivosheina, A. I. Fedorov, E. M. Kazin, I. A. Sviridova, N. N. Koshko, M. S. Kolomeets   +5 more
doaj  

Insights from the COVID-19 pandemic: trends in development assistance committee countries' aid allocation, 2011-2021. [PDF]

Glob Health Action, 2023
Nomura S, Ghaznavi C, Shimizu K, Cao A, Sassa M, Uchibori M, Santosh Kumar R, Yamasaki L, Tomoi H, Sakamoto H.   +9 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

How did COVID-19 impact development assistance for health? - The trend for country-specific disbursement between 2015 and 2020. [PDF]

Glob Health Med, 2023
Wakabayashi M, Hachiya M, Fujita N, Komada K, Obara H, Nozaki I, Okawa S, Saito E, Katsuma Y, Iso H.   +9 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source