Results 131 to 140 of about 1,175,687 (245)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Measuring health financing vulnerability due to reductions in official development assistance: A conceptual framework with empirical application across 47 African countries. [PDF]

PLOS Glob Public Health
Asamani JA, Faye S, Boris Bediakon KS, Kipruto H, Okoroafor SC, Kayita J, Dioka A, Ali A, Droti B, Chukwujekwu O.   +9 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Reductions in development assistance for health funding threaten decades of progress in Africa. [PDF]

PLoS Med
MacPherson P, Nliwasa M, Choko AT.
europepmc   +1 more source

Opportunities and challenges of trilateral South‒South cooperation for transforming development assistance for health: evidence from a DRC-UNICEF-China maternal, newborn, and child health project. [PDF]

Global Health, 2023
Huang A, Cao C, Xiao AY, Karemere H, Christian ME, Nicolas KK, Xue M, Tang K.   +7 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The perceived impacts of United States foreign development assistance reductions on health system building blocks at healthcare facilities in Zambia: A mixed-methods study. [PDF]

PLOS Glob Public Health
Tantum LK, Anderson DM, Halwiindi H, Herce ME, Mbizvo MT, Kirby MA, Cronk R.   +6 more
europepmc   +1 more source

How much bilateral and multilateral climate adaptation finance is targeting the health sector? A scoping review of official development assistance data between 2009-2019. [PDF]

PLOS Glob Public Health, 2023
Alcayna T, O'Donnell D, Chandaria S.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Tracking development assistance for health, 1990-2030: historical trends, recent cuts, and outlook. [PDF]

Lancet
Apeagyei AE, Bisignano C, Elliott H, Hay SI, Lidral-Porter B, Nam S, Shyong C, Tsakalos G, Zlavog BS, Barış E, Murray CJL, Dieleman JL.   +11 more
europepmc   +1 more source