Results 141 to 150 of about 27,612,816 (297)

The IDB: Vol. 24, no. 11, November 1997

open access: yes, 1997
The IDB reports on economic and social development trends in Latin America and the Caribbean and on the activities of the Bank.
Inter-American Development Bank
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The IDB: Vol. 24, no. 9-10, September-October 1997

open access: yes, 1997
The IDB reports on economic and social development trends in Latin America and the Caribbean and on the activities of the Bank.
Inter-American Development Bank
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Nonnegligible Groundwater Depletion From Aquitards in Multilayered Leaky Aquifer Systems

open access: yesGeofluids
Groundwater depletion constitutes a critical global challenge. Exploitation of deep aquifers leads to nonnegligible depletion of water stored in adjacent aquitards (termed aquitard depletion).
Xingyu Chen   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022

open access: yesMicrobiology Spectrum
Since 2015, Taiwan has experienced a notable rise in domestic shigellosis cases, particularly among young adult males. In this study, we aimed to investigate this epidemiological trend through demographic analysis and genomic characterization of ...
Ying-Shu Liao   +9 more
doaj   +1 more source

IDB America: Vol. 26, no. 1-2, January-February 1999

open access: yes, 1999
IDB America reports on economic and social development trends in Latin America and the Caribbean and on the activities of the IDB.
Inter-American Development Bank
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Emergence of azithromycin-resistant extensively drug-resistant Salmonella Kentucky ST314 in Taiwan

open access: yesFrontiers in Microbiology
Salmonella enterica serovar Kentucky (S. Kentucky) has emerged globally as a multidrug-resistant lineage but has historically been rare in Taiwan. Here, we report a recent surge of azithromycin-resistant extensively drug-resistant (AziR-XDR) S.
Ying-Shu Liao   +8 more
doaj   +1 more source

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