Results 191 to 200 of about 4,729,685 (247)

Design and Initial Evaluation of a Low-Cost Microprocessor-Controlled Ankle Prosthesis. [PDF]

Sensors (Basel)
Bigaliyeva Z, Ayazbay AA, Akhmejanov S, Zhetenbayev N, Sultan A, Nurgizat Y, Ussam AJ, Tursunbayeva G, Uzbekbayev A, Ozhikenov K, Sergazin G, Lazzat Y.   +11 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Evolution of the Healthcare System in Saudi Arabia Over the Last Century: A Historical and Policy Analysis. [PDF]

J Healthc Leadersh
Sheerah HA, Alzaaqi SM, Arafa A, Banjar WM, Liu K, Withers M, El-Jardali F, Penttinen P, Al-Jedai AH, Selbie D.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Paternal perinatal mental health and early child development: An outcome-wide analysis. [PDF]

Infant Ment Health J
Scarlett H, Benarous X, Consoli A, Montreuil T, Lyon-Caen S, Philippat C, Waerden JV.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation. [PDF]

J Anim Sci Biotechnol
Yu W, Xia Y, Wang W, Yang Z, Liu Z, Gan X, Zhang M, Zhou B, Li Y, Zhang Y, Cao Z.   +10 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The influence of family care guidance for premature infants based on a telemedicine model on their neurodevelopmental assessment indicators. [PDF]

Front Pediatr
Zuo L, Ye H, Li D.
europepmc   +1 more source

Differential regulation of myopia progression by ON and OFF stimulation in guinea pigs. [PDF]

Eye Vis (Lond)
Xie Q, Dai Q, Zhu X, Chen X, Shen B, Fang Y, Li X, Lu F, Zhou X, Wang M.   +9 more
europepmc   +1 more source