Results 51 to 60 of about 105,241 (264)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Enhanced framework for ensemble effort estimation by using recursive‐based classification

IET Software, 2021
Service‐oriented software engineering is a software engineering methodology focussed on the development of software systems. The systematic application of technological and scientific knowledge depends on the methodology, experience, design for obtaining
Azath Hussain, Maheswari Raja, Pandimurugan Vellaisamy, Sangeetha Krishnan, Lakshminarayanan Rajendran   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Software Estimation in the Design Stage with Statistical Models and Machine Learning: An Empirical Study

Mathematics
Accurate estimation of software effort and time in the software development process is a key activity to achieve the necessary product quality. However, underestimation or overestimation of effort has become a key challenge for software development.
Ángel J. Sánchez-García, María Saarayim González-Hernández, Karen Cortés-Verdín, Juan Carlos Pérez-Arriaga   +3 more
doaj   +1 more source

Peningkatan Akurasi Estimasi Usaha dan Biaya COCOMO II Berdasarkan Gaussian dan BCO

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2017
An accurate effort and cost estimation provides good management for software projects. Less accurate estimation will affect the management of the software project and cause the ineffectiveness of the project development process.
Rahmi Rizkiana Putri, Daniel Oranova Siahaan, Sarwosri   +2 more
doaj   +1 more source

Applying COCOMO II for a DO-178C Safety-Critical Software Effort Estimation

Journal of Aerospace Technology and Management, 2019
This paper provides a real example of applying COCOMO II as an estimation technique for the required software development effort in a safety-critical software application project following the DO-178C processes. The main goal and contribution of the case
Lucas Pereira dos Santos, Maurício Ferreira   +1 more
doaj   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Analogy-based model for software project effort estimation

IJAIN (International Journal of Advances in Intelligent Informatics), 2018
Accurate effort estimation of software development plays an important role to predict how much effort should be prepared during the works of a software project so that it can be completed on time and budget. Some sectors, e.g.
Ardiansyah Ardiansyah, Murein Miksa Mardhia, Sri Handayaningsih   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source