Results 141 to 150 of about 20,516,146 (337)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The Future of Georgia's Nonprofit Leadership [PDF]
, 2005 The aim of this survey of Georgia nonprofits is to better understand how leadership transitions will impact nonprofits, and inform the development of strategies to address the pending generational shift in leaders.
Paige Hull Teegarden
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The quality of district plans and their implementation: Towards environmental quality [PDF]
, 2002 Since inception of the Resource Management Act 1991 (RMA) the issue of sustainable management has dominated planning practice in New Zealand. Over the past decade, councils have wrestled with converting the concept of sustainable management into policy
Backhurst, Michael +7 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Use of individual development plans for nurse scientist training. [PDF]
Nurs Outlook, 2020 Thompson HJ +21 more
europepmc +1 more source
Development of criteria and procedures for the evaluation of the European Action Plan for Organic Agriculture [PDF]
, 2008 This final report provides a synthesis of the results of the EU-funded ORGAP project, with the title “European Action Plan of Organic Food and Farming - Development of criteria and procedures for the evaluation of the EU Action Plan for Organic ...
Dabbert, Stephan +5 more
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Redesigning operational planning system (OPS) for ministry of health and medical education in Iran
Payesh, 2014 Objective (s): Achieving the objectives of planned programs in the Ministry of Health and Medical Education (MOHME) depends on the successful implementation of operational planning (OP). In the last few years an attempt was made to deploy OP in different
Behzad Damari +3 more
doaj