Results 191 to 200 of about 20,516,146 (337)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A Preliminary Study to Determine Comprehensive Research and Development Plans for Promoting Mental Health Services. [PDF]

Osong Public Health Res Perspect, 2018
Kim CE, Ko YM, Lee SU, Choi S, Han K, Park SJ, Jo M, Park YK, Lee HY, Park S.   +9 more
europepmc   +1 more source

Development and Pre-Testing of a Rehabilitation Planning Consultation for Head-and-Neck Cancer

, 2017
Sara McEwen, Colleen Dunphy, Jorge Rios, Aileen M. Davis, Jennifer M. Jones, Andrew C. L. Lam, Ian Poon, Rosemary Martino, Jolie Ringash   +8 more
openalex   +2 more sources

Building planning spaces for the integration of coastal and maritime cultural heritage in local and regional spatial development

, 2022
Carsten Jahn Hansen, Elaine Azzopardi, Irène Béguier, Laura Ferguson, Wesley Flannery, Katia Frangoudès   +5 more
openalex   +2 more sources

The Use of a Visual Testing Apparatus for Space Application Final Report [PDF]

Support services for calibration and development of optimum utilization plans for visual parameter tester applicable to manned space ...
Hoisman, A. J., Moots, A.
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Framework for Evaluating Local Adaptive Capacity to Health Impacts of Climate Change: Use of Kenya's County-Level Integrated Development Plans. [PDF]

Ann Glob Health
Kowalcyk M, Dorevitch S.
europepmc   +1 more source

Patient Preference Studies During Early Drug Development: Aligning Stakeholders to Ensure Development Plans Meet Patient Needs. [PDF]

Front Med (Lausanne), 2019
Cook NS, Cave J, Holtorf AP.
europepmc   +1 more source

Contrasting the development of larval and adult body plans during the evolution of biphasic lifecycles in sea urchins [PDF]

Brennan D. McDonald, Abdull J. Massri, Alejandro Berrío, Maria Byrne, David R. McClay, Gregory A. Wray   +5 more
openalex   +1 more source

Industry 5.0 and National Development Plans

, 2023
Beste ALPASLAN, Serdar Çelik
openalex   +2 more sources